Vitamin D deficiency in Europe: pandemic?
Vitamin D deficiency in Europe: pandemic?
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DOI：
10.3945/ajcn.115.120873
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Kiely M
中科院分区：
文献类型：
--
作者：
Cashman KD;Dowling KG;Škrabáková Z;Gonzalez-Gross M;Valtueña J;De Henauw S;Moreno L;Damsgaard CT;Michaelsen KF;Mølgaard C;Jorde R;Grimnes G;Moschonis G;Mavrogianni C;Manios Y;Thamm M;Mensink GB;Rabenberg M;Busch MA;Cox L;Meadows S;Goldberg G;Prentice A;Dekker JM;Nijpels G;Pilz S;Swart KM;van Schoor NM;Lips P;Eiriksdottir G;Gudnason V;Cotch MF;Koskinen S;Lamberg-Allardt C;Durazo-Arvizu RA;Sempos CT;Kiely M
背景资料：维生素D缺乏症已被描述为大流行病，但欧盟的血清25-羟基维生素D [25（OH）D]分布数据的质量差异很大。NIH领导的国际维生素D标准化计划（VDSP）已经制定了标准化国家健康/营养调查中现有25（OH）D值的协议。目的：本研究将VDSP方案应用于代表性儿童/青少年和成人/老年欧洲人群的血清25（OH）D数据，代表了相当大的地理足迹，以更好地量化欧洲维生素D缺乏症的患病率。设计图：VDSP方案应用于14项人群研究[11项研究中血清25（OH）D亚群的再分析和3项先前未测量的研究中所有样本的完整分析]，方法是使用经认证的液相色谱-串联质谱法对生物库血清进行分析。这些数据与来自4项先前标准化研究的标准化血清25（OH）D数据相结合（总计n = 55，844）。维生素D缺乏的患病率估计[使用各种血清25（OH）D阈值]是根据标准化的25（OH）D数据产生的。结果如下：不考虑年龄组、种族混合和研究人群纬度的总体汇总估计显示，55，844名欧洲人中有13.0%的人血清25（OH）D浓度平均<30 nmol/L，在冬季（12月至3月）和夏季（4月至11月）期间采样的人中分别为17.7%和8.3%。根据维生素D缺乏的另一种建议定义（<50 nmol/L），患病率为40.4%。深色皮肤人种血清25（OH）D <30 nmol/L的患病率比白色人群高得多（3- 71倍）。结论：维生素D缺乏症在整个欧洲人口中很明显，其患病率令人担忧，需要从公共卫生的角度采取行动。这些战略的方向将取决于欧洲的政策，但应旨在确保大多数欧洲人口的维生素D摄入量能够预防维生素D缺乏症。
Background: Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys. Objective: This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe. Design: The VDSP protocols were applied in 14 population studies [reanalysis of subsets of serum 25(OH)D in 11 studies and complete analysis of all samples from 3 studies that had not previously measured it] by using certified liquid chromatography–tandem mass spectrometry on biobanked sera. These data were combined with standardized serum 25(OH)D data from 4 previously standardized studies (for a total n = 55,844). Prevalence estimates of vitamin D deficiency [using various serum 25(OH)D thresholds] were generated on the basis of standardized 25(OH)D data. Results: An overall pooled estimate, irrespective of age group, ethnic mix, and latitude of study populations, showed that 13.0% of the 55,844 European individuals had serum 25(OH)D concentrations <30 nmol/L on average in the year, with 17.7% and 8.3% in those sampled during the extended winter (October–March) and summer (April–November) periods, respectively. According to an alternate suggested definition of vitamin D deficiency (<50 nmol/L), the prevalence was 40.4%. Dark-skinned ethnic subgroups had much higher (3- to 71-fold) prevalence of serum 25(OH)D <30 nmol/L than did white populations. Conclusions: Vitamin D deficiency is evident throughout the European population at prevalence rates that are concerning and that require action from a public health perspective. What direction these strategies take will depend on European policy but should aim to ensure vitamin D intakes that are protective against vitamin D deficiency in the majority of the European population.
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影响因子：
3.4
作者：
Damsgaard, Camilla T.;Dalskov, Stine-Mathilde;Michaelsen, Kim F.
通讯作者：
Michaelsen, Kim F.
影响因子：
5.8
作者：
Grimnes, Guri;Almaas, Bjorg;Jorde, Rolf
通讯作者：
Jorde, Rolf
影响因子：
4.2
作者：
Black, Lucinda J.;Walton, Janette;Kiely, Mairead
通讯作者：
Kiely, Mairead
影响因子：
4.7
作者：
Ginty, F;Cavadini, C;Barclay, DV
通讯作者：
Barclay, DV
影响因子：
3.6
作者：
Damsgaard, Camilla T.;Dalskov, Stine-Mathilde;Michaelsen, Kim F.
通讯作者：
Michaelsen, Kim F.