Towards the optimisation of acoustic fields for ablative therapies of tumours in the upper abdomen
Towards the optimisation of acoustic fields for ablative therapies of tumours in the upper abdomen
复制标题
优化上腹部肿瘤消融治疗的声场
DOI：
10.1088/1742-6596/457/1/012002
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Gélat P
中科院分区：
文献类型：
--
作者：
Gélat P
高强度聚焦超声 (HIFU) 对癌症非侵入性治疗的功效已被证明可用于多种不同的癌症，包括肝癌、肾癌、前列腺癌和乳腺癌。作为一种非侵入性聚焦治疗，HIFU 与化疗和手术切除等其他技术相比，在非侵入性和有害副作用风险低方面具有相当大的优势。然而，目前存在许多重大挑战阻碍其广泛的临床应用。这些挑战之一是需要通过胸腔传输足够的能量以诱导所需病灶处的组织坏死，同时最大限度地减少旁叶的形成并保护健康组织。肋骨强烈吸收和反射超声波。因此，在胸腔后面的区域聚焦超声波的一个常见副作用是骨骼和周围组织过热，这可能导致皮肤烧伤。因此，成功治疗上腹部肿瘤患者需要彻底了解声能和热能的沉积方式。这可能依赖于治疗计划程序，其中获得最佳源速度分布，以便最大化治疗部位处的剂量量，同时确保该量不超过其他场位置处的指定阈值，特别是在肋骨的表面上。此前，开发了一种基于 Burton-Miller 公式的广义最小残差 (GMRES) 实现的边界元方法来预测人体肋骨散射的多元 HIFU 阵列的场，其拓扑是从 CT 扫描数据获得的 [1]。这项工作将边界元方程重新表述为具有非线性约束的最小二乘最小化问题。随后，在具有半球形端盖的完全刚性圆柱形散射体存在的情况下，在球形多元件阵列上以 100 kHz 的激励频率对该方法进行了测试。实现了外部域中的旁瓣和圆柱体表面上的声压大小的减少，同时保留了焦点区域中的局部最大值。
The efficacy of high intensity focused ultrasound (HIFU) for the non-invasive treatment of cancer has been demonstrated for a range of different cancers including those of the liver, kidney, prostate and breast. As a non-invasive focused therapy, HIFU offers considerable advantages over other techniques such as chemotherapy and surgical resection, in terms of its non-invasiveness and low risk of harmful side effects. There is, however, a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the ribcage to induce tissue necrosis at the required foci whilst minimising the formation of side lobes and sparing healthy tissue. Ribs both absorb and reflect ultrasound strongly. As such, a common side effect of focusing ultrasound in regions located behind the rib cage is the overheating of bone and surrounding tissue, which can lead to skin burns. Successful treatment of a patient with tumours in the upper abdomen therefore requires a thorough understanding of the way acoustic and thermal energy are deposited. This is likely to rely on a treatment planning procedure in which optimal source velocity distributions are obtained so as to maximise a dose quantity at the treatment sites, whilst ensuring that this quantity does not exceed a specified threshold at other field locations, particularly on the surface of the ribs. Previously, a boundary element approach based on a Generalised Minimal Residual (GMRES) implementation of the Burton-Miller formulation was developed to predict the field of a multi-element HIFU array scattered by human ribs, the topology of which was obtained from CT scan data [1]. This work describes the reformulation of the boundary element equations as a least-squares minimisation problem with non-linear constraints. The methodology was subsequently tested at an excitation frequency of 100 kHz on a spherical multi-element array in the presence of a perfectly rigid cylindrical scatterer with hemi-spherical end-caps. Reduction of side lobes in the exterior domain and of acoustic pressure magnitudes on the surface of the cylinder were achieved whilst preserving a local maximum in the focal region.
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影响因子：
3.8
作者：
Liu, Hao-Li;Chang, Hsu;Lin, Win-Li
通讯作者：
Lin, Win-Li
影响因子：
3.5
作者：
Marquet, F.;Aubry, J. F.;Tanter, M.
通讯作者：
Tanter, M.
非线性超声传播对高强度脑治疗的影响。
影响因子：
3.8
作者：
G. Pinton;J. Aubry;M. Fink;M. Tanter
通讯作者：
M. Tanter
影响因子：
2.4
作者：
Mast, TD;Hinkelman, LM;Waag, RC
通讯作者：
Waag, RC