Progesterone and the luteal phase: a requisite to reproduction.

Progesterone and the luteal phase: a requisite to reproduction.
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DOI:
10.1016/j.ogc.2014.10.003
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发表时间:
2015-03
影响因子:
3.2
通讯作者:
Young SL
Young SL
中科院分区:
医学3区
文献类型:
--
作者:
Mesen TB;Young SL

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正常的月经周期可以分为两个阶段:卵泡和黄体,这两个阶段以排卵分开,以月经出血的第一天为结束。卵泡期由排卵前卵泡的发育主导,导致雌激素刺激的子宫内膜增殖,而黄体期则产生孕酮,孕酮抑制子宫内膜的增殖并决定子宫内膜的容受性。没有这两个阶段的串联工作,自然繁殖是不可能的。本文主要介绍黄体期的正常生理学,黄体期缺陷的争议,以及黄体期支持在辅助生殖技术中的作用。
The normal menstrual cycle can be divided into two phases: follicular and luteal, which are separated by ovulation and bookended by the first day of menstrual bleeding. The follicular phase is dominated by the development of the preovulatory follicle, resulting in estrogenstimulated endometrial proliferation, whereas the corpus luteum (CL) of its namesake luteal phase produces progesterone, which inhibits endometrial proliferation and determines endometrial receptivity. Without both phases working in series, natural reproduction is not possible. This article focuses on the normal physiology of the luteal phase, investigates the controversy surrounding luteal phase defect, and describes the role of luteal phase support in assisted reproductive technology (ART).
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