Optimising the detection parameters for deep-tissue photoacoustic imaging

Optimising the detection parameters for deep-tissue photoacoustic imaging
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优化深层组织光声成像的检测参数

DOI:
10.1117/12.908813
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发表时间:
2012
期刊:
--
影响因子:
--
通讯作者:
Allen T
Allen T
中科院分区:
--
文献类型:
--
作者:
Allen T

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对于深层组织光声成像,通常使用具有大元件尺寸(>1mm)和相对低的中心频率(<5MHz)的压电超声检测器,因为它们可以提供所需的高灵敏度以实现几厘米的成像深度。然而,这些检测器通常在元件尺寸和带宽方面没有优化。为了识别这些参数,以提高信噪比和空间分辨率,两个模型。第一个是一个数值模型,并被用来研究不同的光声图像的振幅和信噪比的检测器元件的大小的影响。第二个模型用于优化检测器带宽。为此,模拟光声信号的频率内容进行了研究的深度和声源大小的范围。该模型基于圆柱源波动方程的解析解,并考虑了频率相关声衰减的影响。这些模型提供了一个新的框架,优化设计的光声扫描仪的乳房和其他深层组织成像应用。
For deep tissue photoacoustic imaging, piezoelectric ultrasound detectors with large element sizes (>1mm) and relatively low centre frequencies (<5MHz) are generally used, as they can provide the required high sensitivity to achieve imaging depths of several centimetres. However, these detectors are generally not optimised in terms of element size and bandwidth. To identify these parameters in order to improve SNR and spatial resolution, two models were employed. The first was a numerical model and was used to investigate the effect of varying the detector element size on the amplitude and SNR of photoacoustic images. The second model was used to optimise the detector bandwidth. For this, the frequency content of simulated photoacoustic signals were studied for a range of depths and acoustic source sizes. The model was based on an analytical solution to the wave equation for a cylindrical source and incorporated the effects of frequency dependent acoustic attenuation. These models provide a new framework for optimising the design of photoacoustic scanners for breast and other deep tissue imaging applications.
转基因小鼠胚胎的光声成像
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