In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice
In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice
复制标题
小鼠皮下肿瘤体内纵向光声成像
DOI：
10.1117/12.876782
复制
发表时间：
2011
影响因子：
4.6
通讯作者：
P. Beard
中科院分区：
文献类型：
--
作者：
J. Laufer;Peter Johnson;E. Zhang;B. Treeby;B. Cox;B. Pedley;P. Beard
光声断层扫描可以提供血管网络的高分辨率3D图像，使其非常适合表征肿瘤血管系统的发展及其对治疗的反应。在这项研究中，光声图像的深度高达9毫米，使用全光学超声检测方案。研究了皮下植入小鼠的两种类型的结肠直肠肿瘤（LS 174T和SW 1222）。在体内获得3D光声图像，揭示了每种肿瘤类型的不同血管结构及其在几天内的演变。结果表明，光声成像可以发挥作用，提供必要的临床前信息肿瘤病理生理学和引发的生物学机制的抗血管生成治疗和其他治疗。
Photoacoustic tomography can provide high resolution 3D images of vascular networks, making it well suited to characterising the development of tumour vasculature and its response to treatment. In this study, photoacoustic images to depths of up to 9 mm were obtained using an all optical ultrasound detection scheme. Two type of colorectal tumours (LS174T and SW1222) implanted subcutaneously in a mouse were studied. 3D photoacoustic images were obtained in vivo revealing the different vascular architectures of each tumour type and their evolution over a period of several days. The results suggest that photoacoustic imaging could play a role in providing essential pre-clinical information on tumour pathophysiology and eliciting the biological mechanisms underlying anti-angiogenic therapies and other treatments.
影响因子：
3.1
作者：
Folarin AA;Konerding MA;Timonen J;Nagl S;Pedley RB
通讯作者：
Pedley RB
影响因子：
2.1
作者：
Treeby, Bradley E.;Zhang, Edward Z.;Cox, B. T.
通讯作者：
Cox, B. T.