Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis.
Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis.
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DOI：
10.7189/jogh.08.010405
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发表时间：
2018-06
影响因子：
7.2
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Hou H;Zhao Y;Yu W;Dong H;Xue X;Ding J;Xing W;Wang W
阻塞性睡眠呼吸暂停（OSA）是一种睡眠障碍，其特征是在睡眠期间完全或部分上部气流停止。虽然OSA是高血压发生的危险因素已被广泛接受，但针对该主题的研究显示了不一致的结果。我们的目的是阐明阻塞性睡眠呼吸暂停与高血压之间的关系，包括原发性高血压和耐药性高血压。遵循系统性综述和荟萃分析的首选报告项目（PRISMA）。使用PubMed和Embase数据库检索截至2016年12月31日发表的相关研究。采用Meta分析的定量方法估计合并比值比（OR）和95%置信区间（CI）。26项研究（51623例受试者，28314例男性，23309例女性;平均年龄51.8岁）符合入选标准，被纳入本研究。其中6项研究显示OSA与难治性高血压显著相关（合并OR = 2.842，95% CI = 1.703-3.980，P < 0.05）。同时，将20篇关于OSA与原发性高血压相关性的原始研究进行合并，也得到了显著的结果，合并OR为1.184轻度组为1.316（95% CI = 1.197-1.433，P <0.05），中度组为1.561（95% CI = 1.287-1.835，P < 0.05）。我们的研究结果表明，阻塞性睡眠呼吸暂停与顽固性高血压的风险增加。轻、中、重度OSA均与原发性高血压相关，并呈剂量-反应关系。这种关联在白种人和男性OSA患者中相对较强。
Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980, P < 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274, P < 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433, P < 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835, P < 0.05) for severe OSA. Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.
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影响因子：
3.7
作者：
Priou P;Le Vaillant M;Meslier N;Paris A;Pigeanne T;Nguyen XL;Alizon C;Bizieux-Thaminy A;Leclair-Visonneau L;Humeau MP;Gagnadoux F;IRSR sleep cohort group
通讯作者：
IRSR sleep cohort group
不同性别和年龄的失眠患者阻塞性睡眠呼吸暂停的特征
影响因子：
2.5
作者：
Li, Zhe;Li, Yun;Tang, Xiangdong
通讯作者：
Tang, Xiangdong
DOI：
10.1001/jama.2012.3418
发表时间：
2012-05-23
期刊：
JAMA
影响因子：
--
作者：
Marin JM;Agusti A;Villar I;Forner M;Nieto D;Carrizo SJ;Barbé F;Vicente E;Wei Y;Nieto FJ;Jelic S
通讯作者：
Jelic S
影响因子：
3.2
作者：
Bartel, PR;Loock, M;Becker, P
通讯作者：
Becker, P
影响因子：
2.6
作者：
Chan, Po-Fun;Tai, Bee-Choo;Lee, Chi-Hang
通讯作者：
Lee, Chi-Hang