Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas.
Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas.
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DOI：
10.1002/jmri.23675
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发表时间：
2012-08
影响因子：
4.4
通讯作者：
Hou, Bob L.
中科院分区：
文献类型：
--
作者：
Zhang, Na;Zhang, Lijuan;Qiu, Bensheng;Meng, Li;Wang, Xiaoyi;Hou, Bob L.
目的探讨动态磁共振成像（DCE-MRI）和最佳示踪剂动力学参数在胶质性脑肿瘤无创分级中的作用，并进行组织病理学分级（I-IV级）。对28例组织病理学分级胶质瘤患者进行影像学检查。在钆- dtpa注射前获取5个翻转角度的图像，并对其进行处理，计算每个感兴趣区域（ROI）的T1值。根据MRI信号和药代动力学模型对注射过程中获得的所有DCE-MRI数据进行处理，在每位患者肿瘤内绘制的roi、对侧正常区域和单个动脉输入功能（iAIF）区域建立浓度-时间曲线。采用非线性最小二乘拟合方法获得示踪剂动力学参数。各组织病理分级组对这些参数采用Kruskal-Wallis h检验和Mann-Whitney u检验，差异有统计学意义（P<0.05）。利用iaif计算的体积传递系数（Ktrans）和血管外细胞间隙体积分数（Ve）不仅可用于区分低级（即I级和II级）和高级（即III级和IV级）胶质瘤（P(Ktrans) <0.001, PVe<0.001），还可用于区分II级和III级（P(Ktrans) =0.016, PVe=0.033）。Ktrans是无创分级中最敏感和特异的参数，可区分高（III级和IV级）和低（I级和II级）胶质瘤，高III级和低II级胶质瘤。
To evaluate the roles of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and optimum tracer kinetic parameters in the noninvasive grading of the glial brain tumors with histopathological grades (I–IV). Twenty eight patients with histopathologically graded gliomas were imaged. Images with five flip angles were acquired before injection of gadolinium-DTPA and were processed to calculate the T1 value of each regions of interest (ROI). All the DCE-MRI data acquired during the injection were processed based on the MRI signal and pharmacokinetic models to establish concentration-time curves in the ROIs drawn within the tumors, counterlateral normal areas, and area of the individual artery input functions (iAIF) of each patient. A nonlinear least square fitting method was used to obtain tracer kinetic parameters. Kruskal-Wallis H-test and Mann-Whitney U-test were applied to these parameters in different histopathological grade groups for statistical differences (P<0.05). Volume transfer coefficient (Ktrans) and extravascular extracellular space volume fraction (Ve) calculated by using iAIFs can be used not only to distinguish the low (i.e., I and II) from the high (i.e., III and IV) grade gliomas (P(Ktrans) <0.001 and PVe<0.001), but also grade II from III (P(Ktrans) =0.016 and PVe=0.033). Ktrans is the most sensitive and specific parameter in the noninvasive grading, distinguishing the high (III and IV) from the low (I and II) grade and high grade III from low grade II gliomas.
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影响因子：
2.8
作者：
Hasselbalch, Benedikte;Eriksen, Jesper Grau;Lassen, Ulrik
通讯作者：
Lassen, Ulrik
影响因子：
4.4
作者：
Singh, Anup;Rathore, Ram K. Singh;Gupta, Rakesh K.
通讯作者：
Gupta, Rakesh K.
影响因子：
4.4
作者：
Akella, NS;Twieg, DB;Nabors, LB
通讯作者：
Nabors, LB
影响因子：
3.5
作者：
Jain, R.;Ellika, S. K.;Mikkelsen, T.
通讯作者：
Mikkelsen, T.
DOI：
10.1186/1756-6649-9-4
发表时间：
2009-04-07
期刊：
BMC medical physics
影响因子：
--
作者：
Shukla-Dave, Amita;Lee, Nancy;Koutcher, Jason A
通讯作者：
Koutcher, Jason A