Disturbance of sensory filtering in dementia with Lewy bodies: comparison with Parkinson’s disease dementia and Alzheimer’s disease
Disturbance of sensory filtering in dementia with Lewy bodies: comparison with Parkinson’s disease dementia and Alzheimer’s disease
复制标题
路易体痴呆症的感觉过滤障碍：与帕金森病痴呆症和阿尔茨海默病的比较
DOI：
--
复制
发表时间：
2004
影响因子：
11
通讯作者：
A. Destée
中科院分区：
文献类型：
--
作者：
M. Perriol;K. Dujardin;P. Derambure;A. Marcq;J. Bourriez;E. Laureau;F. Pasquier;L. Defebvre;A. Destée
预脉冲抑制（PPI）被认为反映了生物体过滤掉不相关的感觉或认知信息的能力。PPI的破坏从未在患有路易体痴呆（DLB）的个体中进行过研究。由于注意力缺陷在很大程度上导致了DLB患者的认知障碍，因此采用PPI模式的研究有助于DLB与阿尔茨海默病（AD）和帕金森病痴呆（PDD）的鉴别诊断。目的和方法：采用听觉诱发电位N1/P2分量PPI对10例DLB、10例AD和10例PDD患者及10例健康对照的早期注意选择性进行研究。PPI模式由声脉冲（40 ms, 115 dB）和预脉冲（40 ms, 80 dB）组成。声音刺激在总共80个试验中以伪随机顺序呈现。结果：非参数方差分析显示，在120毫秒导联间隔上有显著的组效应。回顾性分析显示，与健康对照组和AD相比，DLB患者的PPI显著降低。PDD组的干扰强度为中等。结论：本研究显示DLB患者存在严重的PPI障碍。DLB患者在大小和时间过程方面表现出特定的中断特征。
Introduction: Prepulse inhibition (PPI) is considered to mirror an organism’s ability to filter out irrelevant sensory or cognitive information. The disruption of PPI has never been studied in individuals suffering from dementia with Lewy bodies (DLB). As attention deficits largely contribute to cognitive impairment in DLB, an investigation with a PPI paradigm is useful for differential diagnosis of DLB versus Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD). Objective and methods: PPI of the N1/P2 component of auditory evoked potentials was used to investigate the early stages of attention selectivity in 10 DLB, 10 AD, and 10 PDD patients, as well as in 10 healthy controls. The PPI paradigm consisted of the presentation of sound pulses (40 ms, 115 dB) preceded by a prepulse (40 ms, 80 dB). Sound stimuli were presented in a total of 80 trials in a pseudo-random order. Results: Non-parametric analyses of variance revealed a significant group effect on the 120 ms lead interval. Retrospective analyses revealed that PPI was significantly reduced in DLB compared to healthy controls and AD. In the PDD group, the disturbance was of intermediate intensity. Conclusion: The present study revealed a severe disturbance of PPI in DLB patients. The DLB patients displayed a specific disruption profile in terms of magnitude as well as time course.
影响因子：
3
作者：
Böhmelt, AH;Schell, AM;Dawson, ME
通讯作者：
Dawson, ME
影响因子：
--
作者：
D. Braff;C. Grillon;M. Geyer
通讯作者：
D. Braff;C. Grillon;M. Geyer