Higher expression of circulating miR-182 as a novel biomarker for breast cancer.
Higher expression of circulating miR-182 as a novel biomarker for breast cancer.
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循环 miR-182 的高表达作为乳腺癌的新型生物标志物
DOI：
10.3892/ol.2013.1593
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发表时间：
2013-12
期刊：
影响因子：
2.9
通讯作者：
Jiang BF
中科院分区：
文献类型：
--
作者：
Wang PY;Gong HT;Li BF;Lv CL;Wang HT;Zhou HH;Li XX;Xie SY;Jiang BF
微小RNA（miRNA）以稳定且可重复的方式存在于血清中，可用作各种疾病的生物标志物。以前很少有研究调查乳腺癌（BC）患者外周血中的循环miRNA。为了明确血清miR-182水平在BC中的作用，本研究采用定量PCR方法检测了46例BC患者和58例对照者血清中miR-182水平。结果显示，乳腺癌患者血清中miR-182水平显著高于健康对照组（P<0.01）。与癌旁组织相比，miR-182在BC组织中也过表达。此外，雌激素受体（ER）阳性患者的血清miR-182水平显著低于ER阴性患者。孕酮受体（PR）阳性患者的血清miR-182水平也低于PR阴性患者。目前的研究强调了与miR-182一致的结果，作为诊断BC的新的和有价值的生物标志物。
MicroRNAs (miRNAs), present in the serum in a stable and reproducible manner, may be used as biomarkers for various diseases. Few studies have previously investigated circulating miRNAs in the peripheral blood of breast cancer (BC) patients. To identify the role of serum miR-182 levels in BC, the present study detected miR-182 levels in the serum of 46 BC patients and 58 controls, by quantitative PCR. The results showed that the serum miR-182 levels in BC patients were significantly higher compared with the serum of healthy controls (P<0.01). The miR-182 was also overexpressed in the BC tissues compared with the para-carcinoma tissues. Furthermore, the serum levels of miR-182 in the estrogen receptor (ER)-positive patients were considerably lower compared with those in the ER-negative patients. The serum levels of miR-182 in the progesterone receptor (PR)-positive patients were also found to be lower compared with those in the PR-negative patients. The current study highlights results consistent with miR-182 as a novel and valuable biomarker for the diagnosis of BC.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
4.5
作者：
Di Leva G;Piovan C;Gasparini P;Ngankeu A;Taccioli C;Briskin D;Cheung DG;Bolon B;Anderlucci L;Alder H;Nuovo G;Li M;Iorio MV;Galasso M;Santhanam R;Marcucci G;Perrotti D;Powell KA;Bratasz A;Garofalo M;Nephew KP;Croce CM
通讯作者：
Croce CM
影响因子：
1.8
作者：
Faheem M;Mahmood H;Khurram M;Qasim U;Irfan J
通讯作者：
Irfan J
影响因子：
16
作者：
Moskwa P;Buffa FM;Pan Y;Panchakshari R;Gottipati P;Muschel RJ;Beech J;Kulshrestha R;Abdelmohsen K;Weinstock DM;Gorospe M;Harris AL;Helleday T;Chowdhury D
通讯作者：
Chowdhury D
影响因子：
3.7
作者：
Hunter, Melissa Piper;Ismail, Noura;Zhang, Xiaoli;Aguda, Baltazar D.;Lee, Eun Joo;Yu, Lianbo;Xiao, Tao;Schafer, Jeffrey;Lee, Mei-Ling Ting;Schmittgen, Thomas D.;Nana-Sinkam, S. Patrick;Jarjoura, David;Marsh, Clay B.
通讯作者：
Marsh, Clay B.