HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.
HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.
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DOI：
10.3892/mco.2020.2140
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发表时间：
2020-12
影响因子：
1.2
通讯作者：
Lundholm L
中科院分区：
文献类型：
--
作者：
Monzen S;Tatara Y;Mariya Y;Chiba M;Wojcik A;Lundholm L
按发病率计算，乳腺癌是世界上第二大常见癌症，2018 年新增病例超过 200 万，并且还在持续增加。浸润性导管癌是这种癌症中最常见的类型，约占所有乳腺癌诊断的 70-80%。特别是过度表达人表皮生长因子受体2（HER2）的乳腺癌具有较强的增殖、迁移和侵袭潜力，需要早期治疗。作者确定并研究了一名对单克隆抗 HER2 抗体疗法、化疗和放疗表现出完全耐药性的患者。 1例乳房切除术后对术后辅助治疗出现耐药的患者选自HER2阳性乳腺癌，该患者的分级为T4bN2aM0，IIIB期。分别通过代谢组学和免疫染色技术对患者样本、血清和癌症组织进行分析。研究外周血清和实体瘤的特征，旨在利用代谢组学技术寻找新的血清生物标志物。发现 HER2 阳性癌组织的出现与鞘磷脂家族的血清浓度之间存在相关性。此外，原发性癌症和复发性癌症中的 HER2 阳性肿瘤组织均表达鞘磷脂酶。这些结果表明，来自该癌组织的鞘磷脂导致治疗抵抗、诱导侵袭和强烈增殖。
Breast cancer is the second most common cancer in the world based on incidence, reaching more than 2 million new cases in 2018, while continuing to increase. Invasive ductal carcinoma is the most common type of this cancer, making up approximately 70-80% of all breast cancer diagnoses. In particular, the type of breast cancer overexpressing human epidermal growth factor receptor 2 (HER2) has potential of strong proliferation, migration and invasion and early treatment is necessary. The authors identified and studied a single patient displaying complete therapeutic resistance to monoclonal anti-HER2 antibody therapy, chemotherapy and radiotherapy. A patient who exhibited resistance to postoperative adjuvant therapy after mastectomy was selected from HER2-positive breast cancer, and this patient had the grade of T4bN2aM0, Stage IIIB. The patient samples, blood serum and cancer tissue, were analyzed by metabolome and immunostaining technique, respectively. The characteristics of peripheral blood serum and solid tumor were investigated, aiming to find new serum biomarker(s) using the metabolomics technique. A correlation between the appearance of HER2-positive cancer tissue and serum concentration of the sphingomyelin family was found. In addition, HER2-positive tumor tissue in both the primary and recurrent cancer express the sphingomyelinase. These results suggest that sphingomyelins from this cancer tissue leads to therapy resistance, induction of invasion and strong proliferation.
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影响因子：
4.6
作者：
Chiba M;Monzen S;Iwaya C;Kashiwagi Y;Yamada S;Hosokawa Y;Mariya Y;Nakamura T;Wojcik A
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影响因子：
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通讯作者：
Noh WC
影响因子：
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作者：
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影响因子：
4
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