Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410.
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410.
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人脐带间充质干细胞来源的细胞外囊泡通过转移 miR-410 促进肺腺癌生长。
DOI：
10.1038/s41419-018-0323-5
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发表时间：
2018-02-13
影响因子：
9
通讯作者：
Su C
中科院分区：
文献类型：
--
作者：
Dong L;Pu Y;Zhang L;Qi Q;Xu L;Li W;Wei C;Wang X;Zhou S;Zhu J;Wang X;Liu F;Chen X;Su C
尽管越来越多的证据表明间充质干细胞（MSCs）与肿瘤生长相关，但其潜在机制仍未得到充分理解。在此，我们首次证明，在异种移植瘤模型中，人脐带间充质干细胞（hUCMSCs）可显著促进肺腺癌细胞（LUAD）的生长。随后，我们观察到，hUCMSCs来源的细胞外囊泡（hUCMSC - EVs）通过对LUAD细胞的直接作用，促进了hUCMSCs介导的LUAD细胞生长。此外，我们发现，hUCMSC - EVs介导的LUAD生长与LUAD细胞增殖增加和凋亡减少有关，同时hUCMSC - EVs传递的miR - 410介导了PTEN表达的降低。我们的研究结果为癌细胞与MSCs之间通过MSC - EV - miRNA进行的细胞间通讯提供了新的见解，并表明对hUCMSC - EVs进行修饰，可能是hUCMSC - EVs临床应用中一种有吸引力的治疗选择，这将减少不必要的副作用。
Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor model. Then, we observed that hUCMSC-derived extracellular vesicles (hUCMSC-EVs) contribute to the hUCMSC-promoted LUAD cell growth through a direct effect on LUAD cells. Furthermore, we showed that hUCMSC-EV-mediated LUAD growth is associated with increased proliferation and decreased apoptosis in LUAD cells, concomitant with reduced PTEN expression mediated by the hUCMSC-EV-transmitted miR-410. Our findings provide novel insights into the intercellular communications between cancer cells and MSCs through MSC-EV-miRNA and suggest that modification of hUCMSC-EVs might be an attractive therapeutic option for the clinical application of hUCMSC-EVs that would reduce unwanted side effects.
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影响因子：
3.3
作者：
Ding, Dah-Ching;Chang, Yu-Hsun;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
DOI：
10.1158/1078-0432.ccr-11-2857
发表时间：
2012-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jang JS;Jeon HS;Sun Z;Aubry MC;Tang H;Park CH;Rakhshan F;Schultz DA;Kolbert CP;Lupu R;Park JY;Harris CC;Yang P;Jen J
通讯作者：
Jen J
影响因子：
9.7
作者：
Huang, Haili;Jiang, Yun;Liu, Gang
通讯作者：
Liu, Gang
影响因子：
5.3
作者：
Hsu, Han-Shui;Lin, Jiun-Han;Hung, Shih-Chieh
通讯作者：
Hung, Shih-Chieh
影响因子：
3.7
作者：
Lee JK;Park SR;Jung BK;Jeon YK;Lee YS;Kim MK;Kim YG;Jang JY;Kim CW
通讯作者：
Kim CW