Targeting the C-type lectins-mediated host-pathogen interactions with dextran.
Targeting the C-type lectins-mediated host-pathogen interactions with dextran.
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DOI：
10.18433/j3n590
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Khan ZK
中科院分区：
文献类型：
--
作者：
Pustylnikov S;Sagar D;Jain P;Khan ZK
Dextran, the α-1,6-linked glucose polymer widely used in biology and medicine, promises new applications. Linear dextran applied as a blood plasma substitute demonstrates a high rate of biocompatibility. Dextran is present in foods, drugs, and vaccines and in most cases is applied as a biologically inert substance. In this review we analyze dextran’s cellular uptake principles, receptor specificity and, therefore, its ability to interfere with pathogen–lectin interactions: a promising basis for new antimicrobial strategies. Dextran-binding receptors in humans include the DC-SIGN (dendritic cell–specific intercellular adhesion molecule 3-grabbing nonintegrin) family receptors: DC-SIGN (CD209) and L-SIGN (the liver and lymphatic endothelium homologue of DC-SIGN), the mannose receptor (CD206), and langerin. These receptors take part in the uptake of pathogens by dendritic cells and macrophages and may also participate in the modulation of immune responses, mostly shown to be beneficial for pathogens per se rather than host(s). It is logical to predict that owing to receptor-specific interactions, dextran or its derivatives can interfere with these immune responses and improve infection outcome. Recent data support this hypothesis. We consider dextran a promising molecule for the development of lectin–glycan interaction-blocking molecules (such as DC-SIGN inhibitors) that could be applied in the treatment of diseases including tuberculosis, influenza, hepatitis B and C, human immunodeficiency virus infection and AIDS, etc. Dextran derivatives indeed change the pathology of infections dependent on DC-SIGN and mannose receptors. Complete knowledge of specific dextran–lectin interactions may also be important for development of future dextran applications in biological research and medicine.
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DOI：
10.1083/jcb.63.3.883
发表时间：
1974-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Caulfield JP;Farquhar MG
通讯作者：
Farquhar MG
DOI：
10.5772/50627
发表时间：
2012-01-01
期刊：
CARBOHYDRATES - COMPREHENSIVE STUDIES ON GLYCOBIOLOGY AND GLYCOTECHNOLOGY
影响因子：
--
作者：
Anderluh, Marko
通讯作者：
Anderluh, Marko
影响因子：
5.4
作者：
Cambi, A;Gijzen, K;Figdor, CG
通讯作者：
Figdor, CG
影响因子：
5.4
作者：
Arrighi, JF;Pion, M;Piguet, V
通讯作者：
Piguet, V
影响因子：
2.8
作者：
Caparrós E;Serrano D;Puig-Kröger A;Riol L;Lasala F;Martinez I;Vidal-Vanaclocha F;Delgado R;Rodríguez-Fernández JL;Rivas L;Corbí AL;Colmenares M
通讯作者：
Colmenares M