Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP‐140 in patients with IgA nephropathy
Detection of activated platelets in urinary sediments by immunofluorescence using monoclonal antibody to human platelet GMP‐140 in patients with IgA nephropathy
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人血小板 GMP-140 单克隆抗体免疫荧光法检测 IgA 肾病患者尿沉渣中活化血小板
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
H. Koide
中科院分区：
文献类型：
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作者：
Y. Tomino;Yoshimi Tsushima;H. Ohmuro;M. Shimizu;T. Kuramoto;I. Shirato;H. Koide
使用单克隆抗颗粒膜蛋白（GMP）-140抗体通过间接免疫荧光法研究尿沉渣中活化血小板的存在。GMP-140通常在活化的血小板和血管内皮细胞上表达。本研究的目的是确定伊加肾病患者尿沉渣中活化血小板的存在是否与肾小球损伤相关。本文对14例伊加肾病和11例无伊加沉积的弥漫性系膜增生性肾小球肾炎（PGN）进行了检测。晚期伊加肾病患者尿沉渣中活化血小板明显增多。尿沉渣中活化血小板占总血小板的比例也增加。提示尿沉渣中血小板活化的检测有助于判断伊加肾病的组织学改变程度。© 1993 Wiley利斯公司
The presence of activated platelets in the urinary sediments was studied by indirect immunofluorescence using monoclonal antigranular membrane protein (GMP)‐140 antibody. GMP‐140 is generally expressed on the activated‐platelets and ‐vascular endothelial cells. The purpose of the present study was to determine if the presence of activated platelets in the urinary sediments is correlated with glomerular injuries in patients with IgA nephropathy. Fourteen patients with IgA nephropathy and 11 patients with diffuse mesangial proliferative glomerulonephritis without glomerular IgA deposition (PGN) were examined. The number of activated platelets in the urinary sediments was markedly increased in patients in the advanced stage of IgA nephropathy. The ratio of activated platelets to total platelets in the urinary sediments was also increased in such patients. It appears that the detection of activated platelets in the urinary sediments is useful in determining the degree of histological changes in IgA nephropathy. © 1993 Wiley‐Liss, Inc.
血小板抗原在人类肾脏疾病中的定位。
影响因子：
19.6
作者：
Miller,K;Dresner,IG;Michael,AF
通讯作者：
Michael,AF