Signalling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria.
Signalling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria.
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DOI：
10.1111/j.1365-3024.2011.01298.x
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发表时间：
2011-09
影响因子：
2.2
通讯作者：
Burns JM Jr
中科院分区：
文献类型：
--
作者：
Weidanz WP;Lafleur G;Kita-Yarbro A;Nelson K;Burns JM Jr
A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia. Blood-stage infections in IL-2Rγc-/y mice failed to cure with parasitemia remaining elevated for >50 days indicating the IL-2Rγc through which all members of the γc family of cytokines signal, has an essential role in protective immunity against blood-stage malaria parasites. In contrast, the curing of parasitemia in IL-2/15Rβ-/- mice, deficient in both IL-2 and IL-15 signaling was significantly delayed but did occur, indicating that neither cytokine plays an essential role in parasite clearance. Moreover, the observation that the time-course of parasitemia in IL-15-/- mice was nearly identical to that seen in controls suggest that the parasitemia-suppressing role of stimulating through the IL-2/15Rβ chainis due to IL-2 signaling and not a redundant function of IL-15.
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DOI：
10.1038/nri2580
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.2
作者：
Seixas, E;Fonseca, L;Langhorne, J
通讯作者：
Langhorne, J
影响因子：
5.4
作者：
VANDERHEYDE, HC;ELLOSO, MM;WEIDANZ, WP
通讯作者：
WEIDANZ, WP
DOI：
10.1084/jem.191.5.771
发表时间：
2000-03-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kennedy MK;Glaccum M;Brown SN;Butz EA;Viney JL;Embers M;Matsuki N;Charrier K;Sedger L;Willis CR;Brasel K;Morrissey PJ;Stocking K;Schuh JC;Joyce S;Peschon JJ
通讯作者：
Peschon JJ
影响因子：
64.8
作者：
GRUN, JL;WEIDANZ, WP
通讯作者：
WEIDANZ, WP