The prevalence and incidence of early-onset dementia among adults with autism spectrum disorder.
The prevalence and incidence of early-onset dementia among adults with autism spectrum disorder.
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DOI：
10.1002/aur.2590
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Shea LL
中科院分区：
文献类型：
--
作者：
Vivanti G;Tao S;Lyall K;Robins DL;Shea LL
自闭症谱系障碍（ASD）成人中早发性痴呆的患病率和发病率目前尚不清楚。在这项病例对照研究中，使用Medicaid Analytic eXtract文件检查了2008 - 2012年期间ASD患者早发性痴呆的患病率和发病率。参与者是30-64岁的成年人，他们是医疗补助受益人，并且仅诊断为ASD（n= 12，648），诊断为ASD合并智力残疾（n= 26，168），诊断为ID而没有ASD（n= 406，570），或者没有ASD也没有ID诊断（n= 798，828）。仅ASD成年人的5年痴呆患病率为4.04%，ASD和合并ID的患者为5.22%。该患病率高于无ASD和无ID个体的痴呆患病率（0.97%），但低于仅ID个体（7.10%）。与普通人群患病率增加相关的风险因素与ASD患者痴呆症风险增加类似。即使在调整这些风险因素后，与普通人群相比，痴呆症在仅患有ASD的个体中更频繁发生（调整后的风险比，1.96; 95%CI，1.69-2.28），以及患有ASD和合并ID的个体（调整后的风险比，2.89; 95%CI，2.62-3.17）。总之，在我们的研究中，65岁以下患有自闭症谱系障碍的成年人被诊断出患有痴呆症的可能性是普通人群的2.6倍。目前尚不清楚被诊断为自闭症谱系障碍的成年人与那些没有自闭症谱系障碍的人相比，是否有更高的风险被诊断为早发性痴呆。在这项研究中，我们第一次检查了全国范围内阿尔茨海默病和其他类型痴呆症在ASD中的患病率和发病率，这些患者年龄在30-64岁之间，参加了美国最大的行为健康服务保险公司Medicaid。医疗补助索赔数据，其中包括受益人收到的诊断信息，表明患有自闭症谱系障碍的成年人被诊断患有早发性阿尔茨海默病和相关痴呆症的可能性是普通人群的2.6倍。
The prevalence and incidence of early-onset dementia among adults with Autism Spectrum Disorder (ASD) is currently unknown. In this case-control study, the prevalence and incidence of early-onset dementia in individuals with ASD was examined during 2008 – 2012 using Medicaid Analytic eXtract files. Participants were 30–64 year-old adults who were Medicaid beneficiaries and had either a diagnosis of ASD only (n=12,648), a diagnosis of ASD with co-occurring Intellectual Disability (n=26,168), a diagnosis of ID without ASD (n=406,570), or no ASD nor ID diagnoses (n=798,828). The 5-Year prevalence of dementia was 4.04% among adults with ASD only, and 5.22% for those with ASD and co-occurring ID. This prevalence was higher compared to the prevalence of dementia in individuals with no ASD and no ID (0.97%), but lower compared to individuals with ID only (7.10%). Risk factors associated with the increased prevalence in the general population were similarly associated with the increased risk of dementia in individuals with ASD. Even after adjusting for these risk factors, compared to the general population, dementia was found to occur more frequently in individuals with ASD only (adjusted hazard ratio, 1.96; 95% CI, 1.69–2.28), as well as individuals with ASD and co-occurring ID (adjusted hazard ratio, 2.89; 95% CI, 2.62–3.17). In conclusion, adults with ASD under the age of 65 were approximately 2.6 times more likely to be diagnosed with dementia compared to the general population in our study. It is unclear whether adults diagnosed with Autism Spectrum Disorder are at higher risk of being diagnosed with early-onset dementia compared to those who are not on the autism spectrum. In this study we examined for the first time the nationwide prevalence and incidence of Alzheimer’s Disease and other types of dementia in ASD in a sample of adults with ASD aged 30–64 years who were enrolled in Medicaid, the largest insurer of behavioral health services in the US. Medicaid claims data, which include information on the diagnoses that beneficiaries receive, suggested that the adults with Autism Spectrum Disorder were approximately 2.6 times more likely to be diagnosed with early-onset Alzheimer’s disease and related dementias compared to the general population.
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影响因子：
3.2
作者：
Cai L;Huang J
通讯作者：
Huang J
影响因子：
14
作者：
通讯作者：
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影响因子：
14
作者：
Hartley, Dean;Blumenthal, Thomas;Wisniewski, Thomas
通讯作者：
Wisniewski, Thomas
影响因子：
5.2
作者：
Burke, James P.;Jain, Anjali;Newschaffer, Craig J.
通讯作者：
Newschaffer, Craig J.
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF