Age-related changes in the musculoskeletal system and the development of osteoarthritis.
Age-related changes in the musculoskeletal system and the development of osteoarthritis.
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DOI：
10.1016/j.cger.2010.03.002
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发表时间：
2010-08
影响因子：
3.3
通讯作者：
Loeser RF
中科院分区：
文献类型：
--
作者：
Loeser RF
骨关节炎（OA）是老年人慢性残疾的最常见原因。虽然传统上认为是关节的“磨损”退行性疾病，但最近的研究表明，骨关节炎的炎症成分包括关节组织中多种细胞因子和趋化因子活性的增加，这些细胞因子和趋化因子的活性增加，从而驱动基质降解酶的产生。肌肉骨骼系统的衰老变化并不是直接导致骨关节炎，而是通过使关节更容易受到其他骨关节炎危险因素（包括异常生物力学、关节损伤、遗传和肥胖）的影响，从而促进骨关节炎的发展。年龄相关的肌肉减少症和骨转换增加也可能导致骨关节炎的发生。了解衰老影响关节组织的基本机制应该为减缓或预防骨关节炎的发展提供新的目标。
Osteoarthritis (OA) is the most common cause of chronic disability in older adults. Although classically considered a “wear and tear” degenerative condition of articular joints, recent studies have demonstrated an inflammatory component to OA that includes increased activity of a number of cytokines and chemokines in joint tissues which drive production of matrix degrading enzymes. Rather than directly causing OA, aging changes in the musculoskeletal system contribute to the development of OA by making the joint more susceptible to the effects of other OA risk factors that include abnormal biomechanics, joint injury, genetics, and obesity. Age-related sarcopenia and increased bone turnover may also contribute to the development of OA. Understanding the basic mechanisms by which aging affects joint tissues should provide new targets for slowing or preventing the development of OA.
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影响因子：
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作者：
Aurich, M;Poole, AR;Cole, AA
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/s0925-4439(02)00158-8
发表时间：
2002-11-20
影响因子：
6.2
作者：
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通讯作者：
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作者：
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