Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication.
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication.
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DOI：
10.1371/journal.pone.0047396
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hibi T
中科院分区：
文献类型：
--
作者：
Saito Y;Suzuki H;Tsugawa H;Imaeda H;Matsuzaki J;Hirata K;Hosoe N;Nakamura M;Mukai M;Saito H;Hibi T
microRNA (miRNA) 是一种小型非编码 RNA，可作为靶基因的内源性沉默子，在人类恶性肿瘤中发挥关键作用。为了研究胃粘膜相关淋巴组织 (MALT) 淋巴瘤的分子发病机制，对 miRNA 表达谱进行了分析。对胃 MALT 淋巴瘤和周围非肿瘤粘膜组织标本的 miRNA 微阵列分析表明，造血特异性 miRNA miR-142 和致癌 miRNA miR-155 在 MALT 淋巴瘤病变中过表达。在对幽门螺杆菌 (H. pylori) 根除没有反应的 MALT 淋巴瘤中，miR-142-5p 和 miR-155 的表达水平显着增加。 miR-142-5p和miR-155的表达水平与胃MALT淋巴瘤病例的临床病程相关。在海尔曼螺杆菌感染的 C57BL/6 小鼠（胃 MALT 淋巴瘤动物模型）中也观察到 miR-142-5p 和 miR-155 的过度表达。此外，miR-142-5p 和 miR-155 抑制促凋亡基因 TP53INP1 作为其靶标。本研究结果表明miR-142-5p和miR-155的过表达在胃MALT淋巴瘤的发病机制中发挥着关键作用。这些 miRNA 可能具有作为胃 MALT 淋巴瘤的治疗靶点和新型生物标志物的潜在应用。
microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed. miRNA microarray analysis with tissue specimens from gastric MALT lymphomas and surrounding non-tumor mucosae revealed that a hematopoietic-specific miRNA miR-142 and an oncogenic miRNA miR-155 were overexpressed in MALT lymphoma lesions. The expression levels of miR-142-5p and miR-155 were significantly increased in MALT lymphomas which do not respond to Helicobacter pylori (H. pylori) eradication. The expression levels of miR-142-5p and miR-155 were associated with the clinical courses of gastric MALT lymphoma cases. Overexpression of miR-142-5p and miR-155 was also observed in Helicobacter heilmannii-infected C57BL/6 mice, an animal model of gastric MALT lymphoma. In addition, miR-142-5p and miR-155 suppress the proapoptotic gene TP53INP1 as their target. The results of this study indicate that overexpression of miR-142-5p and miR-155 plays a critical role in the pathogenesis of gastric MALT lymphoma. These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma.
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影响因子：
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作者：
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通讯作者：
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作者：
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发表时间：
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影响因子：
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作者：
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