Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity.
Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity.
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DOI：
10.3390/metabo11110739
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发表时间：
2021-10-28
期刊：
影响因子：
4.1
通讯作者：
Liang L
中科院分区：
文献类型：
--
作者：
Cao T;Zhao J;Hong X;Wang G;Hu FB;Wang X;Liang L
越来越多的人认识到早期代谢规划在儿童肥胖中的作用。这项研究试图调查新生儿脐带血代谢组是否可以预测未来的BMI。它包括波士顿出生队列中的946名儿童，这是一组高风险但未得到充分研究的美国城市低收入儿童的样本，主要是黑人和西班牙裔儿童，他们在出生时就被登记，并前瞻性地跟踪调查到18岁。脐带血中共检测到376种代谢物。定义了纵向BMI轨迹，并将其分为三种不同的模式：早发性超重和肥胖型(早-Owo)、晚发型超重和肥胖型(晚-Owo)和正常体重轨迹(NW)。多项Logistic回归模型被用来识别单独的代谢物或作为与BMI轨迹相关的网络模块。在946名儿童中，388名、254名和304名分别被归类为Owo早期、Owo晚期和NW。在定义的七个共代谢网络模块中，有两个与早期Owo呈负相关。在两个模块中的68种代谢物中，22种三酰甘油和二甘油与早期失水呈负相关，5种胆固醇酯与早期失水呈正相关。在这个前瞻性出生队列中，我们展示了独特的纵向BMI轨迹，并在相关的生物学途径中发现了与早期OwO相关的多种脐带血浆代谢物。
There is increasing recognition on the role of early life metabolic programming in childhood obesity. This study sought to investigate whether newborn cord blood metabolome can predict future BMI. It included 946 children in the Boston Birth Cohort, a sample of high-risk yet understudied US urban, low-income, predominantly Black and Hispanic children, who were enrolled at birth and followed prospectively up to age 18 years. A total of 376 metabolites were measured in cord blood plasma. Longitudinal BMI trajectories were defined and categorized into three distinct patterns: early onset overweight and obesity (early-OWO), late onset OWO (late-OWO), and normal weight trajectory (NW). Multinomial logistic regression models were used to identify metabolites individually or as network modules associated with BMI trajectories. Of the 946 children, 388, 254, and 304 were classified as early-OWO, late-OWO, and NW, respectively. Of the seven co-metabolomic network modules defined, two were inversely correlated with early-OWO. Among the 68 metabolites within the two modules, 22 triacylglycerols and diacylglycerols were negatively associated with early-OWO; 5 cholesterol esters were positively associated with early-OWO. In this prospective birth cohort, we demonstrated distinctive longitudinal BMI trajectories and identified multiple cord plasma metabolites in relevant biological pathways that were associated with early-OWO.
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影响因子：
3
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影响因子：
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