Validation of T(2) -based oxygen extraction fraction measurement with (15) O positron emission tomography.
Validation of T(2) -based oxygen extraction fraction measurement with (15) O positron emission tomography.
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DOI：
10.1002/mrm.28410
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发表时间：
2021-01
影响因子：
3.3
通讯作者：
Lu, Hanzhang
中科院分区：
文献类型：
--
作者：
Jiang, Dengrong;Deng, Shengwen;Franklin, Crystal G.;O'Boyle, Michael;Zhang, Wei;Heyl, Betty L.;Pan, Li;Jerabek, Paul A.;Fox, Peter T.;Lu, Hanzhang
关键词：
通过与金标准15 O-PET测量结果进行比较，评价基于T2的全脑氧摄取分数（OEF）估计的准确性。16名健康成人受试者在同一天接受MRI和15 O-PET OEF测量。在MRI上，基于受试者特异性红细胞压积，通过自旋标记下T2弛豫（TRUST）MRI定量全脑OEF。将TRUST OEF与15 O-PET产生的全脑平均OEF进行比较。TRUST和15 O-PET全脑OEF测量之间的协议进行了检查组内相关系数（ICC）和绝对OEF值。在10名受试者的一个子集中，还评价了全脑OEF的重测重现性，并在两种模式之间进行了比较。在16名受试者中，TRUST和15 O-PET的平均全脑OEF分别为36.44±4.07%和36.45± 3.65%，两种模式之间无差异（P=0.99）。TRUST全脑OEF与15 O-PET密切相关（N=16，ICC=0.90，P=4×10−7）。TRUST和15 O-PET全脑OEF测量的变异系数分别为1.79±0.67%和2.06± 1.55%，两种模式之间无差异（N=10，P=0.64）。对红细胞压积影响的进一步分析显示，PET OEF和TRUST OEF与假定红细胞压积之间的相关性仍然显著（ICC=0.8，P<2×10−5）。TRUST测量的全脑OEF与金标准15 O-PET非常一致，具有高度可比的准确性和重现性。这些结果表明，TRUST MRI可以提供准确的定量全脑OEF非侵入性。
To evaluate the accuracy of T2-based whole-brain oxygen extraction fraction (OEF) estimation by comparing it with gold standard 15O-PET measurements. Sixteen healthy adult subjects underwent MRI and 15O-PET OEF measurements on the same day. On MRI, whole-brain OEF was quantified by T2-relaxation-under-spin-tagging (TRUST) MRI, based on subject-specific hematocrit. The TRUST OEF was compared to the whole-brain averaged OEF produced by 15O-PET. Agreement between TRUST and 15O-PET whole-brain OEF measurements was examined in terms of intraclass correlation coefficient (ICC) and in absolute OEF values. In a subset of ten subjects, test-retest reproducibility of whole-brain OEF was also evaluated and compared between the two modalities. Across the 16 subjects, the mean whole-brain OEF of TRUST and 15O-PET were 36.44±4.07% and 36.45±3.65%, respectively, showing no difference between the two modalities (P=0.99). TRUST whole-brain OEF strongly correlated with that of 15O-PET (N=16, ICC=0.90, P=4×10−7). The coefficient-of-variation of TRUST and 15O-PET whole-brain OEF measurements were 1.79±0.67% and 2.06±1.55%, respectively, showing no difference between the two modalities (N=10, P=0.64). Further analyses on the effect of hematocrit revealed that correlation between PET OEF and TRUST OEF with assumed hematocrit remained significant (ICC=0.8, P<2×10−5). Whole-brain OEF measured by TRUST was in excellent agreement with gold standard 15O-PET, with highly comparable accuracy and reproducibility. These findings suggest that TRUST MRI can provide accurate quantification of whole-brain OEF non-invasively.
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