Body mass index in chronic heart failure: association with biomarkers of neurohormonal activation, inflammation and endothelial dysfunction.
Body mass index in chronic heart failure: association with biomarkers of neurohormonal activation, inflammation and endothelial dysfunction.
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DOI：
10.1186/1471-2261-13-80
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发表时间：
2013-10-01
影响因子：
2.1
通讯作者：
Kistorp C
中科院分区：
文献类型：
--
作者：
Christensen HM;Schou M;Goetze JP;Faber J;Frystyk J;Flyvbjerg A;Kistorp C
低体重指数（BMI）与慢性心力衰竭（CHF）预后不良相关。BMI与脂联素和N-末端B型利钠肽前体（NT-proBNP）呈负相关。本研究的目的是探讨CHF患者神经激素激活、炎症和内皮功能障碍的新标志物是否与BMI相关。在一项包括171例左心室射血分数（LVEF）≤45%的CHF患者的横断面研究中，评价了BMI对脂联素、α-防御素、高敏C反应蛋白（hsCRP）、和肽素、中段肾上腺髓质素原（MR-proADM）、NT-proBNP和中段A型利钠肽原（MR-proANP）循环血浆浓度的影响。在包括年龄、性别、LVEF、纽约心脏协会心功能分级（NYHA）、估计肾小球滤过率（eGFR）和糖尿病的多变量线性回归分析中，仅NT-proBNP（β = −0.32）和脂联素（β = −0.39）与BMI保持独立相关。MR-proANP与BMI相关，但调整年龄后，这种关系减弱，不再显著。在CHF患者中通常增加的生物标志物中，只有脂联素和NT-proBNP与BMI呈独立的负相关。这表明这两种生物标志物的直接作用增强了CHF中观察到的消耗过程。
Low body mass index (BMI) is associated with a poor outcome in chronic heart failure (CHF). An inverse association between BMI and adiponectin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been reported. The aim of the present study was to investigate whether novel markers of neurohormonal activation, inflammation, and endothelial dysfunction are associated with BMI in CHF. In a cross-sectional study including 171 patients with CHF and a left ventricular ejection fraction (LVEF) ≤45% the impact of BMI on circulating plasma concentrations of adiponectin, α-defensins, high sensitivity C-reactive protein (hsCRP), copeptin, mid-regional pro-adrenomedullin (MR-proADM), NT-proBNP, and mid-regional pro-A-type natriuretic peptide (MR-proANP) were evaluated. In multivariable linear regression analysis including age, sex, LVEF, New York Heart Association functional classification (NYHA), estimated glomerular filtration rate (eGFR), and diabetes, only NT-proBNP (β = −0.32) and adiponectin (β = −0.39) remained independently associated with BMI. MR-proANP was associated with BMI but adjusting for age attenuated the relation being no longer significant. Among biomarkers typically increased in patients with CHF only adiponectin and NT-proBNP demonstrated independent inverse associations with BMI. This indicates a direct effect of these two biomarkers enhancing the wasting process seen in CHF.
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影响因子：
39.3
作者：
McEntegart, Margaret B.;Awede, Bonaventure;McMurray, John J. V.
通讯作者：
McMurray, John J. V.
影响因子：
18.2
作者：
Paulo Araujo, Jose;Lourenco, Patricia;Bettencourt, Paulo
通讯作者：
Bettencourt, Paulo
影响因子：
5.8
作者：
Joseph, Gowsini;Tarnow, Lise;Frystyk, Jan
通讯作者：
Frystyk, Jan
影响因子：
6.9
作者：
Vila, Greisa;Riedl, Michaela;Luger, Anton
通讯作者：
Luger, Anton
影响因子：
3.7
作者：
Christensen, Heidi Marie;Kistorp, Caroline;Faber, Jens
通讯作者：
Faber, Jens