Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars.
Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars.
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DOI：
10.1016/j.celrep.2018.01.016
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发表时间：
2018-02-13
期刊：
影响因子：
8.8
通讯作者：
Bäumler AJ
中科院分区：
文献类型：
--
作者：
Hiyoshi H;Wangdi T;Lock G;Saechao C;Raffatellu M;Cobb BA;Bäumler AJ
由血清型肠沙门氏菌引起的伤寒伤寒的临床表现不同于由伤寒沙门氏菌和其他非伤寒沙门氏菌血清型引起的肠胃炎。不同的临床表现部分归因于伤寒沙门氏菌毒力相关的荚膜多糖（Vi抗原），它通过阻止抗体介导的补体激活来防止吞噬细胞引发呼吸爆发。矛盾的是，副伤寒沙门氏菌A中没有Vi抗原，而副伤寒导致的疾病与伤寒没有什么区别。在这里，我们发现副伤寒沙门氏菌A逃避吞噬细胞呼吸爆发需要很长的O抗原链，其中含有O2抗原来抑制抗体结合。我们认为，避免吞噬细胞呼吸爆发的能力是伤寒沙门氏菌和副伤寒沙门氏菌通过趋同进化独立获得的伤寒沙门氏菌血清型与非伤寒沙门氏菌血清型的区别。
Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars. The different clinical presentations are attributed in part to the virulence-associated capsular polysaccharide (Vi antigen) of S. Typhi, which prevents phagocytes from triggering a respiratory burst by preventing antibody-mediated complement activation. Paradoxically, the Vi antigen is absent from S. Paratyphi A, which causes a disease that is indistinguishable from typhoid fever. Here, we show that evasion of the phagocyte respiratory burst by S. Paratyphi A required very long O antigen chains containing the O2 antigen to inhibit antibody binding. We conclude that the ability to avoid the phagocyte respiratory burst is a property distinguishing typhoidal from non-typhoidal Salmonella serovars that was acquired by S. Typhi and S. Paratyphi A independently through convergent evolution.
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影响因子：
3.7
作者：
Hart PJ;O'Shaughnessy CM;Siggins MK;Bobat S;Kingsley RA;Goulding DA;Crump JA;Reyburn H;Micoli F;Dougan G;Cunningham AF;MacLennan CA
通讯作者：
MacLennan CA
影响因子：
3.1
作者：
PANTOSTI, A;TZIANABOS, AO;KASPER, DL
通讯作者：
KASPER, DL
影响因子：
30.3
作者：
Bronner DN;Faber F;Olsan EE;Byndloss MX;Sayed NA;Xu G;Yoo W;Kim D;Ryu S;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
3.2
作者：
BATCHELOR, RA;HARAGUCHI, GE;HULL, SI
通讯作者：
HULL, SI
影响因子：
1.2
作者：
Davis, Michael R.;Goldberg, Joanna B.
通讯作者：
Goldberg, Joanna B.