Plant protein peptidase inhibitors: an evolutionary overview based on comparative genomics.
Plant protein peptidase inhibitors: an evolutionary overview based on comparative genomics.
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DOI：
10.1186/1471-2164-15-812
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发表时间：
2014-09-25
期刊：
影响因子：
4.4
通讯作者：
Martinez M
中科院分区：
文献类型：
--
作者：
Santamaría ME;Diaz-Mendoza M;Diaz I;Martinez M
多肽酶是植物重要生理过程中的关键蛋白质。虽然蛋白肽酶抑制剂是调节多肽酶活性的重要分子，但它们在不同植物物种中的全球存在仍不清楚。比较基因组分析是获取先进知识的有力工具，可以了解病毒界中肽酶及其抑制剂的存在和进化。对不同植物分类群的代表性物种中多肽酶抑制剂和几组多肽酶进行了基因组比较分析。研究结果指出：i)许多家族中普遍存在分支特异性的肽酶抑制剂，某些家族存在于大多数陆地植物中；ii)多变性是肽酶抑制家族的普遍特征，具有丰富的物种特异性(或分支特异性)基因家族的增殖；iii)不同的植物分支中的肽酶更为保守，如C1a木瓜蛋白酶和S8枯草杆菌蛋白家族存在于所分析的所有物种中；以及iv)肽酶与它们的抑制物之间的中等相关性表明，抑制物的增殖既可以控制内源肽酶，也可以控制外源肽酶。比较基因组学为研究植物多肽酶抑制剂家族提供了有价值的见解，并可以解释导致特定植物分支中目前多变的多肽酶抑制剂谱系的进化原因。本文的在线版本(DOI：10.1186/1471-2164-15-812)包含补充材料，可供授权用户使用。
Peptidases are key proteins involved in essential plant physiological processes. Although protein peptidase inhibitors are essential molecules that modulate peptidase activity, their global presence in different plant species remains still unknown. Comparative genomic analyses are powerful tools to get advanced knowledge into the presence and evolution of both, peptidases and their inhibitors across the Viridiplantae kingdom. A genomic comparative analysis of peptidase inhibitors and several groups of peptidases in representative species of different plant taxonomic groups has been performed. The results point out: i) clade-specific presence is common to many families of peptidase inhibitors, being some families present in most land plants; ii) variability is a widespread feature for peptidase inhibitory families, with abundant species-specific (or clade-specific) gene family proliferations; iii) peptidases are more conserved in different plant clades, being C1A papain and S8 subtilisin families present in all species analyzed; and iv) a moderate correlation among peptidases and their inhibitors suggests that inhibitors proliferated to control both endogenous and exogenous peptidases. Comparative genomics has provided valuable insights on plant peptidase inhibitor families and could explain the evolutionary reasons that lead to the current variable repertoire of peptidase inhibitors in specific plant clades. The online version of this article (doi:10.1186/1471-2164-15-812) contains supplementary material, which is available to authorized users.
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