Interactions of host proteins with the murine leukemia virus integrase.
Interactions of host proteins with the murine leukemia virus integrase.
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DOI：
10.3390/v2051110
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发表时间：
2010-05-05
期刊：
影响因子：
--
通讯作者：
Goff SP
中科院分区：
文献类型：
--
作者：
Studamire B;Goff SP
逆转录病毒感染引起动物的多种癌症和人类的多种疾病，如白血病和获得性免疫缺陷综合征。生产性和有效的前病毒整合是逆转录病毒功能的关键，是建立稳定和生产性感染的关键步骤，以及宿主基因在白血病发生中被激活的机制。宿主因素被广泛预期参与逆转录病毒生命周期的所有阶段，整合酶相互作用因子的鉴定有可能增加我们对传入病毒可能适当的细胞蛋白质靶向和捕获宿主DNA序列的机制的理解。MoMLV整合酶相互作用的宿主因子的鉴定可能是设计有效和良性的基于逆转录病毒的基因治疗载体的关键;理解整合的基本机制的关键;以及设计有效的整合酶抑制剂的关键。本文就MoMLV整合酶相互作用蛋白及其在整合过程中的作用作一综述。
Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome. Productive and efficient proviral integration is critical for retroviral function and is the key step in establishing a stable and productive infection, as well as the mechanism by which host genes are activated in leukemogenesis. Host factors are widely anticipated to be involved in all stages of the retroviral life cycle, and the identification of integrase interacting factors has the potential to increase our understanding of mechanisms by which the incoming virus might appropriate cellular proteins to target and capture host DNA sequences. Identification of MoMLV integrase interacting host factors may be key to designing efficient and benign retroviral-based gene therapy vectors; key to understanding the basic mechanism of integration; and key in designing efficient integrase inhibitors. In this review, we discuss current progress in the field of MoMLV integrase interacting proteins and possible roles for these proteins in integration.
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影响因子：
4.8
作者：
Cherepanov, P;Maertens, G;Debyser, Z
通讯作者：
Debyser, Z
DOI：
10.1073/pnas.90.13.6125
发表时间：
1993-07-01
影响因子：
11.1
作者：
BUKRINSKY, MI;SHAROVA, N;STEVENSON, M
通讯作者：
STEVENSON, M
影响因子：
4.8
作者：
Busschots, K;Vercammen, J;Debyser, Z
通讯作者：
Debyser, Z
影响因子：
2.6
作者：
CHOWDHURY, K;GOULDING, M;FICKENSCHER, H
通讯作者：
FICKENSCHER, H
影响因子：
10.5
作者：
BOWERMAN, B;BROWN, PO;VARMUS, HE
通讯作者：
VARMUS, HE