Reducing Radiation Exposure to Paediatric Patients Undergoing [18F]FDG-PET/CT Imaging.
Reducing Radiation Exposure to Paediatric Patients Undergoing [18F]FDG-PET/CT Imaging.
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DOI：
10.1007/s11307-021-01601-4
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发表时间：
2021-10
影响因子：
3.1
通讯作者：
Kench PL
中科院分区：
文献类型：
--
作者：
Kertész H;Beyer T;London K;Saleh H;Chung D;Rausch I;Cal-Gonzalez J;Kitsos T;Kench PL
研究降低儿科肿瘤患者全身[18 F]FDG-PET/CT研究的注射放射性的可能性，并评估在降低计数水平下飞行时间（TOF）采集对PET图像质量的有用性。本研究纳入了29例在具有TOF功能（555 ps）的Siemens Biograph mCT TrueV系统上接受常规全身PET/CT检查的儿科肿瘤患者（12 F/17 M，3-18岁（中位年龄13岁），体重45±20 kg，BMI 19±4 kg/m2）。平均注射活性为156 ± 45 MBq（3.8 ± 0.8 kg/MBq），并与患者体重成比例。以列表模式（LM）格式收集原始数据，并通过从原始LM数据中随机删除事件进行预处理，以模拟降低水平的[18 F]FDG活性（原始计数的75、50、35、20和10%）。所有数据均使用供应商特定的e7工具仅使用标准OSEM重建，使用OSEM加分辨率恢复（PSF）重建。用添加的TOF（TOF）和PSF+TOF重复重建。通过计算在每个模拟的减少计数水平下采用TOF之前和之后肝脏中的信噪比（SNR）和所有PET阳性病变中的对比度噪声比（CNR）的增益，评价TOF连同减少计数水平的益处。最后，由三名核医学医师在5分制上对50%、75%和100%计数的PSF+TOF图像进行临床评价。重建图像的目视检查未显示PSF+TOF的75%和100%计数水平之间的图像质量存在显著差异。TOF重建和PSF结合的SNR和CNR的改善最大。对于OSEM和PSF重建，SNR和CNR增益均随患者BMI线性增加。观察到这些益处，直到将SNR和CNR的计数分别减少到50%和35%。在评价CNR和SNR时，当使用50%或更高的计数时，使用TOF的益处是明显的。对于[18 F]FDG-PET/CT，全身儿科成像，注射的放射性可以减少到原始剂量的75%，而不会影响PET图像质量。在线版本包含补充材料，可通过10.1007/s11307-021-01601-4获得。
To investigate the possibility of reducing the injected activity for whole-body [18F]FDG-PET/CT studies of paediatric oncology patients and to assess the usefulness of time-of-flight (TOF) acquisition on PET image quality at reduced count levels. Twenty-nine paediatric oncology patients (12F/17M, 3–18 years old (median age 13y), weight 45±20 kg, BMI 19±4 kg/m2), who underwent routine whole-body PET/CT examinations on a Siemens Biograph mCT TrueV system with TOF capability (555ps) were included in this study. The mean injected activity was 156 ± 45 MBq (3.8 ± 0.8 kg/MBq) and scaled to patient weight. The raw data was collected in listmode (LM) format and pre-processed to simulate reduced levels of [18F]FDG activity (75, 50, 35, 20 and 10% of the original counts) by randomly removing events from the original LM data. All data were reconstructed using the vendor-specific e7-tools with standard OSEM only, with OSEM plus resolution recovery (PSF). The reconstructions were repeated with added TOF (TOF) and PSF+TOF. The benefit of TOF together with the reduced count levels was evaluated by calculating the gains in signal-to-noise ratio (SNR) in the liver and contrast-to-noise ratio (CNR) in all PET-positive lesions before and after TOF employed at every simulated reduced count level. Finally, the PSF+TOF images at 50, 75 and 100% of counts were evaluated clinically on a 5-point scale by three nuclear medicine physicians. The visual inspection of the reconstructed images did not reveal significant differences in image quality between 75 and 100% count levels for PSF+TOF. The improvements in SNR and CNR were the greatest for TOF reconstruction and PSF combined. Both SNR and CNR gains did increase linearly with the patients BMI for both OSEM only and PSF reconstruction. These benefits were observed until reducing the counts to 50 and 35% for SNR and CNR, respectively. The benefit of using TOF was noticeable when using 50% or greater of the counts when evaluating the CNR and SNR. For [18F]FDG-PET/CT, whole-body paediatric imaging the injected activity can be reduced to 75% of the original dose without compromising PET image quality. The online version contains supplementary material available at 10.1007/s11307-021-01601-4.
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影响因子：
3.5
作者：
Chang, Tingting;Chang, Guoping;Mawlawi, Osama R.
通讯作者：
Mawlawi, Osama R.
飞行时间宠物对全身肿瘤研究的影响：人类观察者病变检测和定位研究。
DOI：
10.2967/jnumed.110.086678
发表时间：
2011-05
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Surti S;Scheuermann J;El Fakhri G;Daube-Witherspoon ME;Lim R;Abi-Hatem N;Moussallem E;Benard F;Mankoff D;Karp JS
通讯作者：
Karp JS
DOI：
10.1007/s00259-008-0799-9
发表时间：
2008-09-01
影响因子：
9.1
作者：
Lassmann, M.;Biassoni, L.;Franzius, C.
通讯作者：
Franzius, C.
影响因子：
3.5
作者：
Schaefferkoetter, Joshua D.;Yan, Jianhua;Conti, Maurizio
通讯作者：
Conti, Maurizio
DOI：
10.1007/s00259-014-2731-9
发表时间：
2014-05-01
影响因子：
9.1
作者：
Lassmann, Michael;Treves, S. Ted
通讯作者：
Treves, S. Ted