Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.
Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.
复制标题
DOI：
10.1155/2018/4864107
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Bacova Z
中科院分区：
文献类型：
--
作者：
Bakos J;Srancikova A;Havranek T;Bacova Z
催产素信号的异常调节与神经发育障碍的病因学有关。神经发育障碍中的突触功能障碍越来越为人所知，其致病机制可能是潜在的治疗干预的目标。因此，重视催产素及其受体在突触结构、功能和神经元连接中的作用具有重要意义。催产素信号的早期改变可能会干扰神经元的成熟，并可能产生短期和长期的病理后果。在分子水平上，神经发育障碍包括细胞骨架重排和轴突发生的改变，导致突触病变的多样性。催产素受体在突触前和突触后膜的存在和催产素对神经元兴奋性的直接影响，通过调节细胞膜上的离子通道的活性暗示，催产素信号的改变可能参与突触病变。催产素调节神经发生，突触可塑性和细胞骨架排列的某些参数的能力进行了讨论。
Aberrant regulation of oxytocin signaling is associated with the etiology of neurodevelopmental disorders. Synaptic dysfunctions in neurodevelopmental disorders are becoming increasingly known, and their pathogenic mechanisms could be a target of potential therapeutic intervention. Therefore, it is important to pay attention to the role of oxytocin and its receptor in synapse structure, function, and neuron connectivity. An early alteration in oxytocin signaling may disturb neuronal maturation and may have short-term and long-term pathological consequences. At the molecular level, neurodevelopmental disorders include alterations in cytoskeletal rearrangement and neuritogenesis resulting in a diversity of synaptopathies. The presence of oxytocin receptors in the presynaptic and postsynaptic membranes and the direct effects of oxytocin on neuronal excitability by regulating the activity of ion channels in the cell membrane implicate that alterations in oxytocin signaling could be involved in synaptopathies. The ability of oxytocin to modulate neurogenesis, synaptic plasticity, and certain parameters of cytoskeletal arrangement is discussed in the present review.
登录
查看更多内容
影响因子：
3.1
作者：
Bakos J;Zatkova M;Bacova Z;Ostatnikova D
通讯作者：
Ostatnikova D
影响因子：
11.4
作者：
AUDIGIER, S;BARBERIS, C
通讯作者：
BARBERIS, C
影响因子：
5.2
作者：
Cassidy, Suzanne B.;Driscoll, Daniel J.
通讯作者：
Driscoll, Daniel J.
影响因子：
3.5
作者：
Bakos, Jan;Bacova, Zuzana;Ostatnikova, Daniela
通讯作者：
Ostatnikova, Daniela
DOI：
10.1073/pnas.050424697
发表时间：
2000-03-28
影响因子：
11.1
作者：
Brussaard, AB;Wossink, J;Kits, KS
通讯作者：
Kits, KS