Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?
Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?
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大脑中的磷酸肌醇 3-激酶增强剂 (PIKE)：它只是磷酸肌醇 3-激酶/Akt 增强剂吗？
DOI：
10.1515/revneuro-2011-0066
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发表时间：
2012-01-26
影响因子：
4.1
通讯作者：
Ye K
中科院分区：
文献类型：
--
作者：
Chan CB;Ye K
自2000年发现以来，磷酸肌醇3-激酶增强子（PIKE）已被认为是一类控制中枢神经系统（CNS）中磷酸肌醇3-激酶（PI 3 K）和Akt的酶活性的GT3。然而，最近的研究表明，PIKE不仅是PI 3 K/Akt的增强剂，而且还调节其他激酶，包括胰岛素受体酪氨酸激酶和粘着斑激酶。此外，它们还调节转录因子如信号转导子和转录激活子以及核因子κB。事实上，PIKE蛋白参与多种细胞过程，包括控制细胞存活、脑发育、记忆形成、基因转录和代谢。本文综述了PIKE蛋白在中枢神经系统中的功能，并讨论了其在各种神经系统疾病中的潜在意义。
Since its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders.
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影响因子：
25
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通讯作者：
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