Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial.
Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial.
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DOI：
10.3390/nu10070909
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发表时间：
2018-07-16
期刊：
影响因子：
5.9
通讯作者：
Wieringa FT
中科院分区：
文献类型：
--
作者：
Sigh S;Roos N;Chamnan C;Laillou A;Prak S;Wieringa FT
柬埔寨的急性营养不良率仍然很高。人们发现标准的即食治疗食品（RUTF）产品的可接受性很低。因此，开发了NumTrey，一种当地生产的以鱼为基础的RUTF。其目的是评估NumTrey与进口牛奶RUTF相比，在家庭治疗急性营养不良中对6-59个月儿童体重增加的有效性。在一项以体重增加为主要结局的单盲随机对照试验中测试了有效性。在基线和每两周一次的随访时评估人体测量学，直至第8周的终点。总共有121例患者被随机分配到BP-100 TM（n = 61）或NumTrey（n = 60）组。两组之间的平均体重增量无统计学差异（BP-100™和NumTrey分别为1.06 g/kg/天; 95% CI（0.72，1.41）和1.08 g/kg/天; 95% CI（0.75，1.41））。尽管两组的体重增加低于预期的4g/kg/d限制了得出结论的能力，但Rutf组和Rutf组均无优势。当地生产的RUTF对改善柬埔寨的营养干预措施具有高度相关性。在柬埔寨，当地生产的以鱼为基础的RUTF是进口牛奶为基础的RUTF的一种相关替代品，用于治疗SAM。
Cambodia continues to have a high prevalence of acute malnutrition. Low acceptability has been found for standard ready-to-use-therapeutic-food (RUTF) products. Therefore, NumTrey, a locally-produced fish-based RUTF, was developed. The objective was to evaluate the effectiveness of NumTrey compared to an imported milk-based RUTF for weight gain among children aged 6–59 months in the home-treatment for acute malnutrition. Effectiveness was tested in a single-blinded randomized controlled trial with weight gain as the primary outcome. Anthropometry was assessed at baseline and bi-weekly follow-ups until endline at Week 8. In total, 121 patients were randomized into BP-100TM (n = 61) or NumTrey (n = 60). There was no statistical difference in mean weight gain between the groups (1.06 g/kg/day; 95% CI (0.72, 1.41) and 1.08 g/kg/day; 95% CI (0.75, 1.41) for BP-100™ and NumTrey, respectively). In addition, no statistically significant differences in secondary outcomes were found. Although the ability to draw conclusions was limited by lower weight gain than the desired 4 g/kg/day in both groups, no superiority was found for eitherRUTF. A locally produced RUTF is highly relevant to improve nutrition interventions in Cambodia. A locally produced fish-based RUTF is a relevant alternative to imported milk-based RUTF for the treatment of SAM in Cambodia.
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