IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection.
IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection.
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逆转录病毒感染过程中Vβ5+天然调节性T细胞的IL-2独立和TNF-α依赖性扩张。
DOI：
10.4049/jimmunol.1202951
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发表时间：
2013-06-01
期刊：
影响因子：
--
通讯作者：
Hasenkrug KJ
中科院分区：
文献类型：
--
作者：
Myers L;Joedicke JJ;Carmody AB;Messer RJ;Kassiotis G;Dudley JP;Dittmer U;Hasenkrug KJ
Friend病毒(Friend Virus，FV)感染小鼠可诱导调节性T细胞(Tregs)的扩增和激活，从而抑制急性免疫反应，促进慢性感染的建立和维持。过继转移实验和Neuropilin 1的表达表明，这些细胞主要是自然Tregs，而不是病毒特异性的常规CD4+T细胞，后者转化为诱导Tregs。对Treg TCR Vβ链的使用分析显示，Vβ5+Treg亚群具有广泛分布的多克隆反应，其比例很高，已知对内源性逆转录病毒编码的超级抗原有反应。与大多数Treg人群不同，Vβ5+亚群表达终末分化效应细胞的标志，其扩增与抗病毒CD8+T细胞反应水平有关，而不是FV感染水平。令人惊讶的是，V-β5+Treg的扩张和积聚不依赖于IL-2，但依赖于α。这些实验揭示了一种新的途径诱导的亚集特异性Treg。
Friend virus (FV) infection of mice induces the expansion and activation of regulatory T cells (Tregs) that dampen acute immune responses and promote the establishment and maintenance of chronic infection. Adoptive transfer experiments and the expression of Neuropilin 1 indicate that these cells are predominantly natural Tregs rather than virus-specific conventional CD4+ T cells that converted into induced Tregs. Analysis of Treg TCR Vβ chain usage revealed a broadly distributed polyclonal response with a high proportionate expansion of the Vβ5+ Treg subset, which are known to be responsive to endogenous retrovirus-encoded superantigens. In contrast to the major population of Tregs, the Vβ5+ subset expressed markers of terminally differentiated effector cells, and their expansion was associated with the level of the antiviral CD8+ T cell response rather than the level of FV infection. Surprisingly, the expansion and accumulation of the Vβ5+ Tregs was IL-2 independent but dependent upon TNFα. These experiments reveal a subset-specific Treg induction by a new pathway.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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