Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering.
Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering.
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DOI：
10.1016/j.biotechadv.2013.12.012
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发表时间：
2014-03
影响因子：
16
通讯作者：
Alsberg, Eben
中科院分区：
文献类型：
--
作者：
Cheng, Christina W.;Solorio, Loran D.;Alsberg, Eben
关键词：
对于骨科医生来说，肌肉骨骼缺陷的重建是一个长期的挑战。肌肉骨骼损伤，如骨折、软骨损伤、感染和肿瘤剥离，往往会导致大的组织空洞，需要用组织移植重建。自体移植目前是骨科组织重建的黄金标准；然而，在损害供体部位之前，可以采集的组织数量是有限的。使用同种或异种脱细胞的骨、软骨、骨骼肌、肌腱和韧带的组织工程策略已成为潜在的替代治疗方法。细胞外基质为细胞的附着、增殖和分化提供了天然的支架。体外细胞来源的基质的脱细胞也可以从组织特异性细胞或祖细胞产生自体构建物。尽管脱细胞骨组织已广泛应用于骨科临床，但脱细胞软骨、骨骼肌、肌腱和韧带细胞来源的基质的兴奋潜力直到最近才开始被探索，最终移植到骨科临床。
The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor debulking can often lead to large tissue voids requiring reconstruction with tissue grafts. Autografts are currently the gold standard in orthopaedic tissue reconstruction; however, there is a limit to the amount of tissue that can be harvested before compromising the donor site. Tissue engineering strategies using allogeneic or xenogeneic decellularized bone, cartilage, skeletal muscle, tendon and ligament have emerged as promising potential alternative treatment. The extracellular matrix provides a natural scaffold for cell attachment, proliferation and differentiation. Decellularization of in vitro cell-derived matrices can also enable the generation of autologous constructs from tissue specific cells or progenitor cells. Although decellularized bone tissue is widely used clinically in orthopaedic applications, the exciting potential of decellularized cartilage, skeletal muscle, tendon and ligament cell-derived matrices has only recently begun to be explored for ultimate translation to the orthopaedic clinic.
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DOI：
10.1302/0301-620x.85b2.13543
发表时间：
2003-03-01
影响因子：
--
作者：
Bentley, G;Biant, LC;Pringle, J
通讯作者：
Pringle, J
DOI：
10.2106/00004623-200209000-00001
发表时间：
2002-09-01
影响因子：
5.3
作者：
Beynnon, BD;Johnson, RJ;Renstrom, P
通讯作者：
Renstrom, P
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
4.8
作者：
Barber-Westin, SD;Noyes, FR;Shaffer, BL
通讯作者：
Shaffer, BL
影响因子：
2.9
作者：
BERNARD, MP;CHU, ML;PROCKOP, DJ
通讯作者：
PROCKOP, DJ