Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?
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DOI:
10.3389/fmicb.2011.00002
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发表时间:
2011
影响因子:
5.2
通讯作者:
Torrelles JB
Torrelles JB
中科院分区:
生物学2区
文献类型:
--
作者:
Sasindran SJ;Torrelles JB

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结核病仍然是世界上的一个主要健康问题。结核分枝杆菌与宿主的最初相互作用标志着感染途径和随后的宿主炎症反应。在感染的不同阶段,这种炎症反应受到宿主和细菌的严格调控。随着感染的进展,最初观察到的强烈促炎反应受到平衡炎症的抑制性介质的调节。在这种环境下,结核分枝杆菌在干扰宿主炎症反应的情况下挣扎求生。在这篇综述中,我们讨论了参与炎症的主要效应分子与结核分枝杆菌感染的不同阶段有关。
Tuberculosis is still a major health problem in the world. Initial interactions between Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent host inflammatory response. This inflammatory response is tightly regulated by both the host and the bacterium during different stages of infection. As infection progresses, the initial intense pro-inflammatory response observed is regulated by suppressive mediators balancing inflammation. In this environment, M. tuberculosis battles to survive interfering with the host inflammatory response. In this review we discuss the major effector molecules involved in inflammation in relation to the different stages of M. tuberculosis infection.
DOI: 10.4049/jimmunol.181.8.5545
发表时间: 2008-10-15
期刊: Journal of immunology (Baltimore, Md. : 1950)
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