Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.
Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.
复制标题
DOI：
10.4049/jimmunol.181.8.5545
复制
发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Turner J
中科院分区：
文献类型：
--
作者：
Beamer GL;Flaherty DK;Assogba BD;Stromberg P;Gonzalez-Juarrero M;de Waal Malefyt R;Vesosky B;Turner J
IL-10是一种潜在的免疫调节性细胞因子，影响先天和获得的免疫调查，尽管IL-10在肺结核期间的IL-10产生（TB）的免疫学后果是未知的小鼠使用结核分枝杆菌敏感的CBA/J小鼠，我们表明IL-10在慢性感染过程中的作用稳定肺细菌量并改善了这种有益结果，与T细胞募集到肺部，并增强了T细胞IFN-γ的产生对人类预防重新激活结核病的重要诊断和/或治疗意义。
IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune responses. The immunological consequences of IL-10 production during pulmonary tuberculosis (TB) are currently unknown, although IL-10 has been implicated in reactivation TB in humans and with TB disease in mice. Using Mycobacterium tuberculosis-susceptible CBA/J mice, we show that blocking the action of IL-10 in vivo during chronic infection stabilized the pulmonary bacterial load and improved survival. Furthermore, this beneficial outcome was highly associated with the recruitment of T cells to the lungs and enhanced T cell IFN-γ production. Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans.
登录
查看更多内容
影响因子：
6.4
作者：
Jung, YJ;Ryan, L;North, RJ
通讯作者：
North, RJ
影响因子：
32.4
作者：
Koppelman, B;Neefjes, JJ;Malefyt, RD
通讯作者：
Malefyt, RD
影响因子：
3.7
作者：
Olobo, JO;Geletu, M;Britton, S
通讯作者：
Britton, S
影响因子：
3.1
作者：
Saunders, BM;Frank, AA;Cooper, AM
通讯作者：
Cooper, AM
影响因子：
3.1
作者：
Bonecini-Almeida, MG;Ho, JL;Silva, JRLE
通讯作者：
Silva, JRLE