Intramyocardial triglyceride quantification by magnetic resonance spectroscopy: In vivo and ex vivo correlation in human subjects.
Intramyocardial triglyceride quantification by magnetic resonance spectroscopy: In vivo and ex vivo correlation in human subjects.
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DOI：
10.1002/mrm.22734
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发表时间：
2011-05
影响因子：
3.3
通讯作者：
Bashir, Adil
中科院分区：
文献类型：
--
作者：
O'Connor, Robert D.;Xu, Jian;Ewald, Gregory A.;Ackerman, Joseph J. H.;Peterson, Linda R.;Gropler, Robert J.;Bashir, Adil
甘油三酯（TG）在心脏组织中的积累与左心室功能的变化有关。质子磁共振波谱（1H-MRS）是目前唯一一种无创的在体测量心肌TG含量的方法。本研究的主要目的是确定这些体内测量是否对人类受试者的心肌TG具有特异性。因此，在原位心脏移植患者（n = 8）进行常规活检前立即进行体内1H-MRS测量，并对肌内膜活检样本进行体外测量。两次测量之间的相关系数为0.97，p < 0.005，首次证明了人体心脏体内测量的特异性。从伴随的可靠性实验中，体内1H-MRS方法的标准化典型误差估计为7.0%，95%置信区间为5.5%至9.4%。结果表明，1H-MRS是一种特异、可靠的心肌TG含量测定方法，适用于常规研究。
Accumulation of triglycerides (TG) in heart tissue has been associated with changes in left ventricular function. Proton magnetic resonance spectroscopy (1H-MRS) is currently the only non-invasive in vivo method to measure myocardial TG content. The primary aim of this study was to determine if these in vivo measurements are specific to myocardial TG in human subjects. Thus, in vivo 1H-MRS measurements were conducted on orthotopic heart transplant patients (n = 8) immediately before they underwent routine biopsies and ex vivo measurements were made on the endomyocardial biopsy samples. The correlation coefficient between the two measurements was 0.97, with p < 0.005, demonstrating for the first time the specificity of the in vivo measurement in human heart. From accompanying reliability experiments, the standardized typical error for the in vivo 1H-MRS method was estimated to be 7.0%, with a 95% confidence interval from 5.5 to 9.4%. These results suggest that 1H-MRS provides a specific and reliable measurement of myocardial TG content and is suitable for routine studies.
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影响因子：
19.7
作者：
Torriani, M;Thomas, BJ;Palmer, WE
通讯作者：
Palmer, WE
影响因子：
4.8
作者：
Sharma, S;Adrogue, JV;Taegtmeyer, H
通讯作者：
Taegtmeyer, H
影响因子：
37.8
作者：
van der Meer, Rutger W.;Rijzewijk, Luuk J.;Diamant, Michaela
通讯作者：
Diamant, Michaela
影响因子：
9.8
作者：
Hopkins, WG
通讯作者：
Hopkins, WG
DOI：
10.1111/j.1559-4572.2009.00061.x
发表时间：
2009-09
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
--
作者：
O'Connor RD;Bashir A;Cade WT;Yarasheski KE;Gropler RJ
通讯作者：
Gropler RJ