The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics.
The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics.
复制标题
吸入硫酸对青少年哮喘患者肺功能的影响。
DOI：
10.1164/arrd.1983.128.2.221
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Horike,M
中科院分区：
文献类型：
--
作者：
Koenig,JQ;Pierson,WE;Horike,M
对10例外源性哮喘和运动性支气管痉挛的青少年受试者进行研究。受试者在安静状态下暴露30分钟，然后在跑步机上进行适度运动时暴露于100微克/立方米氯化钠(NaC L)或100微克/立方米硫酸(H_2SO_4)气雾剂中10分钟。所有暴露在相对湿度约为75%、温度为22°C的环境中，当受试者坐在人体体表时，记录暴露前、暴露期间和暴露后的肺功能测量。运动期间暴露在氯化钠气雾剂中的最大呼气流量下降幅度很小(12%)，但显著下降(p<；0.05)。然而，暴露在H_2SO_4气雾剂中，肺功能的其他三个参数：、FEV1和总呼吸阻力(RT)也发生了显著的变化。这些变化与一组类似的外源性哮喘青少年暴露在0.5ppm二氧化硫中的报告相似。我们的结果是首次报道了一组青少年哮喘受试者暴露于硫酸后的可逆性肺功能改变。
Ten adolescent subjects with extrinsic asthma and exercise-induced bronchospasm were studied. The subjects were exposed for 30 min at rest followed by 10 min during moderate exercise on a treadmill to either 100 µg/m3sodium chloride (NaCl) or 100 µg/m3sulfuric acid (H2SO4) droplet aerosols. All exposures were at approximately 75% relative humidity and 22° C. Pulmonary functional measurements were recorded before, during, and after exposure while the subject was seated in a body Plethysmograph. Exposure to the NaCl aerosol during exercise produced a small (12%) but significant drop in maximal expiratory flow () (p < 0.05). However, exposure to the H2SO4aerosol produced larger reductions in (29%; p < 0.01) and also significant changes in 3 other parameters of pulmonary function: , FEV1, and total respiratory resistance (Rt). The changes were similar to those reported for exposure to 0.5 ppm of sulfur dioxide in a similar group of adolescents with extrinsic asthma. Our results are the first report of reversible pulmonary functional changes after H2SO4exposure in a group of adolescent asthmatic subjects.
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DOI：
--
发表时间：
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期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
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通讯作者：
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