Bile Acids and Biliary Fibrosis.
Bile Acids and Biliary Fibrosis.
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作者：
Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blood. Cholestasis may worsen with biliary fibrosis. Furthermore, bile acid levels, composition and homeostasis are dysregulated in PBC and PSC. In fact, mounting data from animal models and human cholangiopathies suggest that bile acids play a crucial role in the pathogenesis and progression of biliary fibrosis. The identification of bile acid receptors has advanced our understanding of various signaling pathways involved in regulating cholangiocyte functions and the potential impact on biliary fibrosis. We will also briefly review recent findings linking these receptors with epigenetic regulatory mechanisms. Further detailed understanding of bile acid signaling in the pathogenesis of biliary fibrosis will uncover additional therapeutic avenues for cholangiopathies.
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DOI：
10.1038/modpathol.2011.212
发表时间：
2012-05
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1111/febs.12446
发表时间：
2013-12
期刊：
The FEBS journal
影响因子：
--
作者：
Adada M;Canals D;Hannun YA;Obeid LM
通讯作者：
Obeid LM
影响因子：
2
作者：
L Ng KV;Nguyễn LT
通讯作者：
Nguyễn LT
影响因子：
15.9
作者：
Alvaro, D;Alpini, G;Benedetti, A
通讯作者：
Benedetti, A
影响因子：
12.6
作者：
Bowlus, Christopher L.;Pockros, Paul J.;Bedossa, Pierre
通讯作者：
Bedossa, Pierre