HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans.
HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans.
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DOI：
10.1038/s41598-020-75290-4
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发表时间：
2020-10-30
影响因子：
4.6
通讯作者：
Brittain EL
中科院分区：
文献类型：
--
作者：
Zola CE;Duncan MS;So-Armah K;Crothers KA;Butt AA;Gibert CL;Kim JWW;Lim JK;Re VL 3rd;Tindle HA;Freiberg MS;Brittain EL
丙型肝炎病毒(丙型肝炎病毒)可能会增加艾滋病毒携带者(PLWH)患肺动脉高压(PH)的风险。以前关于这一主题的研究相对较少，并调查了选定的人群。我们确定HIV/丙型肝炎病毒混合感染是否与较高的肺动脉收缩压(PASP)和普遍存在的超声心动图PH有关。我们对6032名(16%艾滋病毒/丙型肝炎混合感染)退伍军人老年队列研究参与者进行了横断面分析，研究参与者于2003年4月1日至2012年9月30日接受超声心动图PASP测量。我们进行了多元线性和Logistic回归分析，以确定与未感染的个体相比，HIV/丙型肝炎病毒单一感染或合并感染是否与PASP和PH相关。HIV/丙型肝炎合并感染者的PASP显著高于未感染者(=1.10，95%CI 0.01，2.20)，但HIV/丙型肝炎合并感染者与PH值之间无相关性。子集分析分别和联合检查艾滋病毒和丙型肝炎疾病严重程度标志物。在PLWH中，丙型肝炎病毒混合感染(=1.47，95%CI 0.2 6，2.67)和CD 4 + 细胞计数(= − 0.68，95%CI − 1.10， − 0.2 7)与PASP有关，而与HIV病毒载量和ART方案无关。在丙型肝炎病毒携带者中，HIV混合感染和丙型肝炎病毒生物标志物都与PASP无关。在接受超声心动图检查的美国退伍军人中，艾滋病毒/丙型肝炎病毒混合感染与临床上肺压力显著升高无关。较低的CD4T细胞绝对计数与 + 呈负相关，这值得在前瞻性研究中进一步研究。
Hepatitis C virus (HCV) may increase pulmonary hypertension (PH) risk among people living with HIV (PLWH). Prior studies on this topic have been relatively small and examined selected populations. We determine whether HIV/HCV coinfection is associated with higher pulmonary artery systolic pressure (PASP) and prevalent echocardiographic PH. We performed a cross-sectional analysis of 6032 (16% HIV/HCV coinfected) Veterans Aging Cohort Study participants enrolled 4/1/2003–9/30/2012 with echocardiographic PASP measures. We performed multiple linear and logistic regression analyses to determine whether HIV/HCV mono- or co-infection were associated with PASP and PH compared to uninfected individuals. Individuals with HIV/HCV coinfection displayed a higher PASP than uninfected individuals (=1.10, 95% CI 0.01, 2.20) but there was no association between HIV/HCV coinfection and prevalent PH. Subset analyses examined HIV and HCV disease severity markers separately and jointly. Among PLWH, HCV coinfection (=1.47, 95% CI 0.26, 2.67) and CD4 + cell count (= − 0.68, 95% CI − 1.10, − 0.27), but not HIV viral load nor ART regimen, were associated with PASP. Among people with HCV, neither HIV coinfection nor HCV biomarkers were associated with PASP. Among US veterans referred for echocardiography, HIV/HCV coinfection was not associated with a clinically significant elevation in pulmonary pressure. Lower absolute CD4 + T-cell count was inversely associated with PASP which warrants further investigation in prospective studies.
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影响因子：
39
作者：
Freiberg MS;Chang CC;Kuller LH;Skanderson M;Lowy E;Kraemer KL;Butt AA;Bidwell Goetz M;Leaf D;Oursler KA;Rimland D;Rodriguez Barradas M;Brown S;Gibert C;McGinnis K;Crothers K;Sico J;Crane H;Warner A;Gottlieb S;Gottdiener J;Tracy RP;Budoff M;Watson C;Armah KA;Doebler D;Bryant K;Justice AC
通讯作者：
Justice AC
DOI：
10.1164/rccm.201708-1555oc
发表时间：
2018-04-01
影响因子：
24.7
作者：
Brittain, Evan L.;Duncan, Meredith S.;Freiberg, Matthew
通讯作者：
Freiberg, Matthew
影响因子：
3
作者：
Justice, Amy C.;Dombrowski, Elizabeth;Bryant, Kendall
通讯作者：
Bryant, Kendall
影响因子：
1.9
作者：
Gonzalez Guilabert, Maria Isabel;Hinojosa Mena-Bernal, Carmen;del Pozo Perez, Miguel Angel
通讯作者：
del Pozo Perez, Miguel Angel
影响因子：
37.8
作者：
White, Jessica R.;Chang, Chung-Chou H.;Freiberg, Matthew S.
通讯作者：
Freiberg, Matthew S.