Effect of 1,25(OH)2 vitamin D3 and ionized Ca2+ on 45Ca uptake by primary cultures of aortic myocytes of spontaneously hypertensive and Wistar Kyoto normotensive rats.
Effect of 1,25(OH)2 vitamin D3 and ionized Ca2+ on 45Ca uptake by primary cultures of aortic myocytes of spontaneously hypertensive and Wistar Kyoto normotensive rats.
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1,25(OH)2 维生素 D3 和离子化 Ca2 对自发性高血压大鼠和 Wistar京都正常血压大鼠主动脉肌细胞原代培养物吸收 45Ca 的影响。
DOI：
10.1016/0006-291x(87)90795-9
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发表时间：
1987
影响因子：
3.1
通讯作者：
D. McCarron
中科院分区：
文献类型：
--
作者：
R. Bukoski;H. Xue;D. McCarron
研究了整个动物Ca2+稳态的几种调节剂对从自发性高血压(SHR)和正常血压Wistar京都(WKY)大鼠中分离的主动脉肌细胞的原代培养物摄取45Ca的影响。将汇合细胞暴露于无血清培养基中的1.0、1.25或1.50 mM离子化Ca 2+ 7天，导致SHR而非WKY细胞中较高浓度Ca 2+ 的45 Ca摄取增加。 1,25 (OH)2 维生素 D3 (1 ng/ml) 持续 7 天会导致 SHR 和 WKY 的细胞流入增加，而甲状旁腺激素 (1–34) (1 ng/ml) 则没有效果。数据表明，用于调节整个动物Ca2+稳态的体液因子也可能在血管平滑肌细胞Ca2+代谢的调节中发挥作用。
The effect of several regulators of whole animal Ca2+homeostasis on45Ca uptake by primary cultures of aortic myocytes isolated from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats was examined. Exposure of confluent cells to 1.0, 1.25 or 1.50 mM ionized Ca2+in serum-free medium for seven days resulted in increased45Ca uptake at the higher concentrations of Ca2+in cells of the SHR but not the WKY. 1,25 (OH)2vitamin D3(1 ng/ml) for 7 days caused enhanced influx in cells from both the SHR and WKY while parathyroid hormone (1–34) (1 ng/ml) was without effect. The data indicate that humoral factors that serve to regulate whole animal Ca2+homeostasis may also play a role in the regulation of Ca2+metabolism of the vascular smooth muscle cell.
1,25-二羟基维生素 D3 刺激培养的成年大鼠心室心肌细胞摄取 45Ca2。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Walters,MR;Ilenchuk,TT;Claycomb,WC
通讯作者：
Claycomb,WC
影响因子：
39.2
作者：
RESNICK, LM;MULLER, FB;LARAGH, JH
通讯作者：
LARAGH, JH