Quantitative sensory testing: identifying pain characteristics in patients with osteoarthritis.
Quantitative sensory testing: identifying pain characteristics in patients with osteoarthritis.
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DOI：
10.1016/j.joca.2021.09.011
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发表时间：
2022-01
影响因子：
7
通讯作者：
Neogi T
中科院分区：
文献类型：
--
作者：
Arant KR;Katz JN;Neogi T
本文综述了最常用的定量感觉测试，以确定疼痛敏感。我们研究了定量感觉测试（QST）测量与OA症状和严重程度之间的横向关联，沿着QST结果与OA手术和非手术治疗反应之间的纵向关联。我们在PubMed中检索了英文论文，包括“骨关节炎”和“定量感觉测试”作为检索词。排除了与OA或QST无关的论文。疼痛压力阈值（PPT）、条件性疼痛调制（CPM）和时间总和（TS）是最常用于识别疼痛致敏的QST指标。研究结果表明，膝关节OA的人往往表现出较低的PPT阈值，低效的CPM，并促进TS相比，控制谁没有OA，支持QST的判别效度。治疗前QST在识别膝关节OA手术和非手术治疗疼痛缓解较少的患者方面取得了一定的成功。治疗后QST显示，在关节置换术成功的患者中，PPT和CPM有时可以正常化（PPT阈值增加，CPM变得有效）。最近的研究表明，QST措施更密切相关的疼痛严重程度比OA的放射学严重程度，这表明敏化可能是一种特质，而不是一种状态。QST可能在识别易受慢性疼痛影响的人方面发挥作用，并可能为个性化，更有效的OA治疗提供机会。
This review outlines the most commonly used quantitative sensory tests to identify pain sensitization. We examine cross-sectional associations between quantitative sensory testing (QST) measures and OA symptoms and severity, along with longitudinal associations between QST findings and response to surgical and non-surgical treatments for OA. We conducted a search in PubMed for English language papers including ‘osteoarthritis’ and ‘quantitative sensory testing’ as search terms. Papers that did not pertain specifically to OA or QST were excluded. Pain Pressure Threshold (PPT), Conditioned Pain Modulation (CPM), and Temporal Summation (TS) are the QST measures used most frequently to identify pain sensitization. Findings indicate that persons with knee OA often exhibit lower PPT thresholds, inefficient CPM, and facilitated TS as compared with controls who do not have OA, supporting the discriminant validity of QST. Pre-treatment QST has shown some success in identifying persons who experience less pain relief from surgical and non-surgical treatments for knee OA. Post-treatment QST has shown that sometimes PPT and CPM can normalize (PPT thresholds increase, and CPM becomes efficient) in patients for whom joint replacement is successful. Recent studies indicate that QST measures are more closely associated with pain severity than OA radiographic severity, suggesting that sensitization may be a trait rather than a state. QST may have a role in identifying persons who are susceptible to chronic pain and may offer an opportunity for personalized, more effective treatment of OA.
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影响因子：
7.4
作者：
Kennedy DL;Kemp HI;Ridout D;Yarnitsky D;Rice ASC
通讯作者：
Rice ASC
影响因子：
7
作者：
Bannuru, R. R.;Osani, M. C.;McAlindon, T. E.
通讯作者：
McAlindon, T. E.
DOI：
10.1002/art.24120
发表时间：
2008-10-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Imamura, Marta;Imamura, Satiko Tomikawa;Camanho, Gilberto Luis
通讯作者：
Camanho, Gilberto Luis
影响因子：
2
作者：
Arendt-Nielsen, Lars;Fernandez-de-las-Penas, Cesar;Graven-Nielsen, Thomas
通讯作者：
Graven-Nielsen, Thomas
影响因子：
1.9
作者：
Jaber, Khalid;O'Leary, Shaun;McAuliffe, Michael
通讯作者：
McAuliffe, Michael