Regression methods when the eye is the unit of analysis.
Regression methods when the eye is the unit of analysis.
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DOI：
10.3109/09286586.2012.674614
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发表时间：
2012-06
影响因子：
1.8
通讯作者：
Rosner B
中科院分区：
文献类型：
--
作者：
Glynn RJ;Rosner B
在视觉研究中，眼睛通常是结果的测量单位，也经常是协变量的测量单位，同一个人的两只眼睛的测量结果通常是强烈的，但远非完全相关。在分析方法的开发和可访问性方面取得了进展，以评估眼睛特异性结果的决定因素，包括来自某些受试者双眼的信息。我们说明了可用的回归方法来分析相关的结果，从双眼的数据集与眼睛和受试者特定的曝光和潜在的混杂变量。我们考虑了横断面和纵向研究设计，以及离散、连续和事件发生时间结局。在一系列的研究设计和测量尺度的结果变量，我们显示低估的P值和置信区间的宽度时，发生在一个人的配对眼睛之间的相关性被忽略，和精度降低，发生在单独的分析右眼或左眼，或在分析的人，而不是眼睛。相比之下，以眼睛为分析单位并适当考虑配对结果之间的相关性的回归模型通常最大限度地利用可用数据，增强协变量-结果关联的可解释性，并有效利用仅对分析贡献一只眼睛的受试者的信息。对于视觉研究中的许多研究，现在广泛使用的回归模型，适当地将眼睛作为分析单位，提供了最佳的分析方法。
The eye is often the unit of measurement for outcomes, and frequently also for covariates, in vision research, and measurements in the two eyes of the same person are often strongly but far from perfectly correlated. Advances have occurred in development and accessibility of analytic approaches to evaluate determinants of eye-specific outcomes including information from both eyes of some subjects. We illustrate available regression approaches to analyze correlated outcomes from both eyes in data sets with both eye- and subject-specific exposures and potential confounding variables. We consider cross-sectional and longitudinal study designs, and discrete, continuous, and time-to-event outcomes. Across a range of study designs and measurement scales for the outcome variable, we show the under-estimation of P-values and widths of confidence intervals that occurs when the correlation between paired eyes in a person is ignored, and the reduced precision that occurs in separate analyses of right or left eyes, or in analyses of persons rather than eyes. By comparison, regression models with the eye as the unit of analysis and appropriate consideration of the correlation between paired outcomes generally offer maximal use of available data, enhanced interpretability of covariate-outcome associations, and efficient use of information from subjects who contribute only one eye to analyses. For many studies in vision research, the now widely available regression models that appropriately treat the eye as the unit of analysis offer the best analytic approach.
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影响因子：
2
作者：
GLYNN, RJ;ROSNER, B
通讯作者：
ROSNER, B
影响因子：
5
作者：
Glynn, RJ;Rosner, B
通讯作者：
Rosner, B
影响因子：
1.9
作者：
ROSNER, B
通讯作者：
ROSNER, B
影响因子：
1.9
作者：
ROSNER, B
通讯作者：
ROSNER, B
影响因子：
--
作者：
GLYNN, RJ;ROSNER, B
通讯作者：
ROSNER, B