Dendritic cells in the host response to implanted materials.

Dendritic cells in the host response to implanted materials.
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DOI:
10.1016/j.smim.2017.04.002
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发表时间:
2017-03
影响因子:
7.8
通讯作者:
Lewis JS
Lewis JS
中科院分区:
医学2区
文献类型:
--
作者:
Keselowsky BG;Lewis JS

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树突状细胞(DC)及其靶向调控在机体对植入材料的反应中的作用是一个重要的发展中的研究领域,也是基于生物材料的免疫工程新兴领域的一个重要组成部分。树突状细胞在免疫系统中的关键地位是连接先天免疫和获得性免疫的桥梁,其类型和功能的丰富多样性促进了树突状细胞在免疫系统中的关键地位,并使其成为合成和自然来源的生物材料的关键媒介。这篇综述介绍了关于DC生物学的最新观点,并总结了DC对植入生物材料的反应的最新发现。基于这些发现,有希望对生物材料的特定应用DC响应进行定向编程,使其能够实现并增强几乎与更大的生物材料领域本身一样多样化的应用。
The role of dendritic cells (DCs) and their targeted manipulation in the body’s response to implanted materials is an important and developing area of investigation, and a large component of the emerging field of biomaterials-based immune engineering. The key position of DCs in the immune system, serving to bridge innate and adaptive immunity, is facilitated by rich diversity in type and function and places DCs as a critical mediator to biomaterials of both synthetic and natural origins. This review presents current views regarding DC biology and summarizes recent findings in DC responses to implanted biomaterials. Based on these findings, there is promise that the directed programming of application-specific DC responses to biomaterials can become a reality, enabling and enhancing applications almost as diverse as the larger field of biomaterials itself.
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