Chemically Treated 3D Printed Polymer Scaffolds for Biomineral Formation.
Chemically Treated 3D Printed Polymer Scaffolds for Biomineral Formation.
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DOI：
10.1021/acsomega.8b00219
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发表时间：
2018-04-30
期刊：
影响因子：
4.1
通讯作者：
Bear JC
中科院分区：
文献类型：
--
作者：
Jackson RJ;Patrick PS;Page K;Powell MJ;Lythgoe MF;Miodownik MA;Parkin IP;Carmalt CJ;Kalber TL;Bear JC
我们提出了通过3D打印合成尼龙-12支架，并证明了它们作为细胞生长，分化和生物矿物形成基质的多功能性。我们证明了打印部件的多孔性使其非常适合直接掺入预制纳米材料或材料前体，从而产生具有非常不同的性能和细胞生长环境的纳米复合材料。添加剂，例如来源于在低温下施加的原硅酸四乙酯的那些，部分由于多孔基质的高表面积，促进了细胞的成功生长。预先合成的氧化铁纳米颗粒的掺入导致了一种材料，该材料显示出响应于施加的交流磁场的快速加热，这是用于基因表达的优异特性，并且进一步改进，无化学灭菌。这些方法还避免了改变聚合物原料和污染甚至损坏常用的选择性激光烧结打印机。本文提出的化学处理的3D打印基质具有很大的潜力，可用于解决当前围绕骨移植、植入物和骨骼修复的问题，并且各种可能的结合材料组合可能影响许多其他领域。
We present the synthesis of nylon-12 scaffolds by 3D printing and demonstrate their versatility as matrices for cell growth, differentiation, and biomineral formation. We demonstrate that the porous nature of the printed parts makes them ideal for the direct incorporation of preformed nanomaterials or material precursors, leading to nanocomposites with very different properties and environments for cell growth. Additives such as those derived from sources such as tetraethyl orthosilicate applied at a low temperature promote successful cell growth, due partly to the high surface area of the porous matrix. The incorporation of presynthesized iron oxide nanoparticles led to a material that showed rapid heating in response to an applied ac magnetic field, an excellent property for use in gene expression and, with further improvement, chemical-free sterilization. These methods also avoid changing polymer feedstocks and contaminating or even damaging commonly used selective laser sintering printers. The chemically treated 3D printed matrices presented herein have great potential for use in addressing current issues surrounding bone grafting, implants, and skeletal repair, and a wide variety of possible incorporated material combinations could impact many other areas.
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DOI：
10.1002/adma.201501099
发表时间：
2015-07-15
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Hong S;Sycks D;Chan HF;Lin S;Lopez GP;Guilak F;Leong KW;Zhao X
通讯作者：
Zhao X
影响因子：
9.9
作者：
Bear, Joseph C.;Gomez, Virginia;Dunnill, Charles W.
通讯作者：
Dunnill, Charles W.
影响因子：
6.3
作者：
Ho, HCH;Gibson, I;Cheung, WL
通讯作者：
Cheung, WL
影响因子：
8.6
作者：
Caruso, F;Spasova, M;Caruso, RA
通讯作者：
Caruso, RA
DOI：
10.1007/s10856-013-4900-y
发表时间：
2013-06-01
影响因子：
3.7
作者：
Hernandez-Escolano, M.;Juan-Diaz, M. J.;Gurruchaga, M.
通讯作者：
Gurruchaga, M.