Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.
Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.
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DOI：
10.1016/j.bmc.2014.11.021
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Debbab A
中科院分区：
文献类型：
--
作者：
Kabbaj FZ;Lu S;Faouzi Mel A;Meddah B;Proksch P;Cherrah Y;Altenbach HJ;Aly AH;Chadli A;Debbab A
对摩洛哥药用植物Thymelaea lythroides的内生真菌Chaetomium aureum的EtOAc提取物进行化学研究，得到一种新的间苯二酚衍生物，命名为毛癣酚，以及五种已知的代谢产物。分离的化合物的结构进行了测定的基础上的一维和二维NMR光谱和高分辨率质谱，以及通过与文献比较。使用孕酮受体（PR）和兔网织红细胞裂解物（RRL）测试所有化合物在体外对Hsp 90伴侣机器的活性。在分离的化合物中，只有scleroclavin有效地抑制Hsp 90机器伴侣活性。然而，scleroclavin对乳腺癌Hs 578 T、MDA-MB-231和前列腺癌LNCaP细胞系没有显示出细胞毒性作用。有趣的是，在48小时的时间段内，scleroclavin的脱乙酰化增加了其对测试细胞系的细胞毒性。
Chemical investigation of the EtOAc extract of the fungus Chaetomium aureum, an endophyte of the Moroccan medicinal plant Thymelaea lythroides, afforded one new resorcinol derivative named chaetorcinol, together with five known metabolites. The structures of the isolated compounds were determined on the basis of one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry as well as by comparison with the literature. All compounds were tested for their activity towards the Hsp90 chaperoning machine in vitro using the progesterone receptor (PR) and rabbit reticulocyte lysate (RRL). Among the isolated compounds, only sclerotiorin efficiently inhibited the Hsp90 machine chaperoning activity. However, sclerotiorin showed no cytotoxic effect on breast cancer Hs578T, MDA-MB-231 and prostate cancer LNCaP cell lines. Interestingly, deacetylation of sclerotiorin increased its cytotoxicity toward the tested cell lines over a period of 48h.
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影响因子：
14.8
作者：
Kjer, Julia;Debbab, Abdessamad;Proksch, Peter
通讯作者：
Proksch, Peter
影响因子：
5.1
作者：
Isaka, M;Jaturapat, A;Thebtaranonth, Y
通讯作者：
Thebtaranonth, Y
DOI：
10.1080/13651820600985259
发表时间：
2007-01-01
期刊：
HPB : the official journal of the International Hepato Pancreato Biliary Association
影响因子：
--
作者：
Marwah, Sanjay;Khan, Mohammed Mustafizur Rahman;Nundy, Samiran
通讯作者：
Nundy, Samiran
影响因子：
3.6
作者：
Donnelly, Alison C.;Mays, Jared R.;Burlison, Joseph A.;Nelson, John T.;Vielhauer, George;Holzbeierlein, Jeffrey;Blagg, Brian S. J.
通讯作者：
Blagg, Brian S. J.
影响因子：
11.2
作者：
McCollum AK;TenEyck CJ;Stensgard B;Morlan BW;Ballman KV;Jenkins RB;Toft DO;Erlichman C
通讯作者：
Erlichman C