Recent advances in drug delivery systems for enhancing drug penetration into tumors.
Recent advances in drug delivery systems for enhancing drug penetration into tumors.
复制标题
增强药物渗透到肿瘤的药物输送系统的最新进展
DOI：
10.1080/10717544.2020.1831106
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发表时间：
2020-12
期刊：
影响因子：
6
通讯作者：
Cong H
中科院分区：
文献类型：
--
作者：
He B;Sui X;Yu B;Wang S;Shen Y;Cong H
纳米给药材料的出现为避免全身给药的副作用和肿瘤切除引起的损伤提供了机会，为未来的癌症治疗带来了巨大的希望。然而，目前纳米药物的疗效并不明显优于原有的药物治疗。重要的原因是纳米药物进入肿瘤血管，停留在血管附近，无法进入肿瘤组织或肿瘤细胞完成给药过程。药物渗透肿瘤效率低已成为制约纳米药物发展的瓶颈。在此，我们系统地概述了纳米药物载体在药物输送系统中的设计进展，以增强药物对肿瘤的渗透。全文分为四个部分：药物在肿瘤组织中的渗透过程包括细胞旁转运和细胞外转运。然后介绍了促进肿瘤渗透的策略，包括重塑肿瘤微环境、电荷反转、尺寸变化和促进组织渗透的配体表面修饰的方法。最后对药物渗透研究的未来发展进行了简要的展望。本文旨在通过综述促进纳米药物内吞入肿瘤细胞的策略，为有效治疗癌症提供思路。
Abstract The emergence of nanomaterials for drug delivery provides the opportunity to avoid the side effects of systemic drug administration and injury caused by the removal of tumors, delivering great promise for future cancer treatments. However, the efficacy of current nano drugs is not significantly better than that of the original drug treatments. The important reason is that nano drugs enter the tumor vasculature, remaining close to the blood vessels and unable to enter the tumor tissue or tumor cells to complete the drug delivery process. The low efficiency of drug penetration into tumors has become a bottleneck restricting the development of nano-drugs. Herein, we present a systematic overview of recent advances on the design of nano-drug carriers in drug delivery systems for enhancing drug penetration into tumors. The review is organized into four sections: The drug penetration process in tumor tissue includes paracellular and transcellular transport, which is summarized first. Strategies that promote tumor penetration are then introduced, including methods of remodeling the tumor microenvironment, charge inversion, dimensional change, and surface modification of ligands which promote tissue penetration. Conclusion and the prospects for the future development of drug penetration are finally briefly illustrated. The review is intended to provide thoughts for effective treatment of cancer by summarizing strategies for promoting the endocytosis of nano drugs into tumor cells.
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