Monocyte recruitment during infection and inflammation.
Monocyte recruitment during infection and inflammation.
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DOI：
10.1038/nri3070
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发表时间：
2011-10-10
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--
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单核细胞起源于骨髓中的祖细胞，并通过血流运输到外周组织。在稳态和炎症期间，循环单核细胞离开血流并迁移到组织中，在通过局部生长因子、促炎细胞因子和微生物产物调节后，它们分化成巨噬细胞或树突状细胞群。单核细胞的募集对于有效控制和清除病毒、细菌、真菌和原生动物感染是必不可少的，但募集的单核细胞也有助于炎性和退行性疾病的发病机制。在稳态、感染和炎症条件下控制单核细胞运输的机制正在被解开，这是本文的重点。
Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, pro-inflammatory cytokines and microbial products, they differentiate into macrophage or dendritic cell populations. Recruitment of monocytes is essential for effective control and clearance of viral, bacterial, fungal and protozoal infections, but recruited monocytes also contribute to the pathogenesis of inflammatory and degenerative diseases. The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review.
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