MicroRNA-196: critical roles and clinical applications in development and cancer.
MicroRNA-196: critical roles and clinical applications in development and cancer.
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DOI：
10.1111/j.1582-4934.2010.01219.x
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发表时间：
2011-01
影响因子：
5.3
通讯作者：
Yao Q
中科院分区：
文献类型：
--
作者：
Chen C;Zhang Y;Zhang L;Weakley SM;Yao Q
microRNAs （miRNAs）的发现是近十年来生物和医学领域最重要的进展之一。在植物、病毒、动物和人类中已经发现了数百种mirna，这些微小的非编码RNA转录物在涉及人类健康和疾病的重要生物过程中起着至关重要的作用。最近，许多研究表明，miR-196在正常发育和人类疾病过程（如癌症）的发病机制中发挥着关键作用。一些研究已经通过细胞培养和动物模型来探索miR-196的潜在分子机制。这篇综述提供了关于miR-196基因结构和miR-196在发育、癌症和疾病形成中的作用的最新信息。重要的是，我们讨论了miR-196调节细胞功能的可能分子机制，包括靶向分子和基因调控途径；讨论了潜在的临床应用，以及未来的研究方向。miR-196a可能被证明是几种癌症的新的治疗靶点。
The discovery of microRNAs (miRNAs) represents one of the most significant advances in biological and medical sciences in the last decade. Hundreds of miRNAs have been identified in plants, viruses, animals and human beings, and these tiny, non-coding RNA transcripts have been found to play crucial roles in important biological processes involved in human health and disease. Recently, many studies have demonstrated that miR-196 plays critical roles in normal development and in the pathogenesis of human disease processes such as cancer. Several investigations have implemented cell culture and animal models to explore the potential molecular mechanisms of miR-196. This review provides updated information about the structure of the miR-196 gene and the roles of miR-196 in development, cancer and disease formation. Importantly, we discuss the possible molecular mechanisms whereby miR-196 regulates cellular functions including targeting molecules and gene regulation pathways; potential clinical applications are addressed, as well as future directions for investigation. miR-196a may prove to be a novel therapeutic target for several cancers.
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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