Magnetic resonance guided, focal laser induced interstitial thermal therapy in a canine prostate model.
Magnetic resonance guided, focal laser induced interstitial thermal therapy in a canine prostate model.
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DOI：
10.1016/j.juro.2010.05.091
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Ward JF
中科院分区：
文献类型：
--
作者：
Stafford RJ;Shetty A;Elliott AM;Klumpp SA;McNichols RJ;Gowda A;Hazle JD;Ward JF
To evaluate a newly FDA-cleared closed-loop, magnetic resonance (MR)-guided laser-induced interstitial thermal therapy (LITT) system for targeted ablation of prostate tissue in order to assess targeting ability, lesion generation and feasibility. Mongrel dogs with (n = 2) and without (n = 5) canine transmissible venereal tumors in the prostate were imaged with a 1.5-T MR imaging scanner. Real-time 3D MR imaging was used to accurately position water-cooled 980-nm laser applicators to pre-determined targets within the canine prostates. Destruction of targeted tissue was guided with MR temperature imaging in real time for precise control of thermal ablation. MR predictions of thermal damage were correlated with findings from post-treatment images and compared to histopathology. Template-based targeting using MR guidance allowed the laser applicator to be placed within a mean of 1.1 mm (SD = 0.7 mm) of the target location. The mean width and length of the ablation zone by MR were 13.7 mm (SD = 1.3 mm) and 19.0 mm (SD = 4.2 mm) using single and compound exposures. The thermal damage predicted by MR correlated with the thermal damage determined by post-treatment imaging with a slope near unity and excellent correlation (R2 = 0.94). This LITT system provided rapid and localized heating of tissue with minimal collateral thermal spread or injury. Combined with real-time monitoring and template-based planning, MR-guided LITT is an attractive modality for prostate cancer focal therapy.
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影响因子：
4.4
作者：
Hazle, JD;Diederich, CJ;Stafford, RJ
通讯作者：
Stafford, RJ
影响因子：
2.1
作者：
Zerbib, Marc;Zelefsky, Michael J.;Carroll, Peter R.
通讯作者：
Carroll, Peter R.
影响因子：
2.1
作者：
Coad, JE;Kosari, K;Sielaff, TD
通讯作者：
Sielaff, TD
DOI：
10.1016/j.mric.2005.04.008
发表时间：
2005-08-01
影响因子：
1.6
作者：
Jolesz, Ferenc A;Hynynen, Kullervo;Tempany, Clare
通讯作者：
Tempany, Clare
影响因子：
2.1
作者：
Marberger, Michael;Carroll, Peter R.;Abenhaim, Lucien L.
通讯作者：
Abenhaim, Lucien L.