Sex-specific urinary biomarkers for diagnosing bipolar disorder.
Sex-specific urinary biomarkers for diagnosing bipolar disorder.
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DOI：
10.1371/journal.pone.0115221
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Chen JJ;Huang H;Zhao LB;Zhou DZ;Yang YT;Zheng P;Yang DY;He P;Zhou JJ;Fang L;Xie P
基于性别的差异在情感障碍中很突出，但没有生物标志物可用于支持性别特异性，基于实验室的诊断男性和女性双相情感障碍（BD）患者。在这里，基于NMR的代谢组学方法被用来初步确定性别特异性尿代谢物生物标志物，用于诊断男性和女性BD患者。由4种代谢物（α-羟基丁酸盐、胆碱、甲酸盐和N-甲基烟酰胺）组成的男性特异性生物标志物组有效区分了男性BD和健康对照（HC）受试者，获得了0.942的受试者工作特征曲线下面积（AUC）。由4种代谢物（α-羟基丁酸酯、乙酸异丙酯、丙酮和N-甲基烟酰胺）组成的女性特异性生物标志物组有效区分了女性BD和HC受试者，AUC为0.909。男性特异性生物标志物组在女性组中显示出低辨别力，并且女性特异性生物标志物组在男性组中显示出低辨别力。此外，其他几种代谢产物在男性和女性BD受试者之间显示出不同的趋势。这些研究结果表明，男性和女性BD患者具有不同的生物标志物指纹，这两种性别特异性生物标志物面板可以作为区分男性和女性BD患者与其健康对应者的有效诊断工具。我们的工作可能会提供一个窗口，潜在的机制，BD的病因在男性和女性。
Sex-based differences are prominent in affective disorders, but there are no biomarkers available to support sex-specific, laboratory-based diagnostics for male and female bipolar disorder (BD) patients. Here, a NMR-based metabonomic approach was used to preliminarily identify sex-specific urinary metabolite biomarkers for diagnosing male and female BD patients. A male-specific biomarker panel consisting of four metabolites (α-hydroxybutyrate, choline, formate, and N-methylnicotinamide) effectively discriminated between male BD and healthy controls (HC) subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.942. A female-specific biomarkers panel consisting of four metabolites (α-hydroxybutyrate, oxalacetate, acetone, and N-methylnicotinamide) effectively discriminated between female BD and HC subjects, achieving an AUC of 0.909. The male-specific biomarker panel displayed low discriminatory power in the female group, and the female-specific biomarker panel displayed low discriminatory power in the male group. Moreover, several other metabolites showed different trends between male and female BD subjects. These findings suggest that male and female BD patients have distinct biomarker fingerprints and that these two sex-specific biomarker panels may serve as effective diagnostic tools in distinguishing male and female BD patients from their healthy counterparts. Our work may provide a window into the mechanisms underlying the pathoetiology of BD in both men and women.
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影响因子：
3.7
作者：
Jia HM;Feng YF;Liu YT;Chang X;Chen L;Zhang HW;Ding G;Zou ZM
通讯作者：
Zou ZM
精神分裂症的潜在代谢标志物
影响因子：
11
作者：
Yang J;Chen T;Sun L;Zhao Z;Qi X;Zhou K;Cao Y;Wang X;Qiu Y;Su M;Zhao A;Wang P;Yang P;Wu J;Feng G;He L;Jia W;Wan C
通讯作者：
Wan C
DOI：
10.1016/s1068-607x(00)00030-5
发表时间：
2000-05-01
期刊：
Primary care update for Ob/Gyns
影响因子：
--
作者：
Hilty;Kelly;Hales
通讯作者：
Hales
影响因子：
8
作者：
Bradley, AP
通讯作者：
Bradley, AP
影响因子：
2.4
作者：
Bylesjo, Max;Rantalainen, Mattias;Trygg, Johan
通讯作者：
Trygg, Johan