Potential metabolite markers of schizophrenia.
Potential metabolite markers of schizophrenia.
复制标题
精神分裂症的潜在代谢标志物
DOI：
10.1038/mp.2011.131
复制
发表时间：
2013-01
影响因子：
11
通讯作者：
Wan C
中科院分区：
文献类型：
--
作者：
Yang J;Chen T;Sun L;Zhao Z;Qi X;Zhou K;Cao Y;Wang X;Qiu Y;Su M;Zhao A;Wang P;Yang P;Wu J;Feng G;He L;Jia W;Wan C
精神分裂症是一种严重的精神障碍，影响全球0.5-1%的人口。目前的诊断方法是基于精神病学访谈，这是主观的。缺乏疾病生物标志物来支持客观的实验室检查一直是精神分裂症临床诊断和评估的长期瓶颈。在这里，我们报告了一项全球代谢谱研究，涉及112名精神分裂症患者和110名健康受试者，他们被分为一个训练集和一个测试集，旨在确定代谢物标志物。由甘油酸、二十碳烯酸、β-羟基丁酸、丙酮酸和胱氨酸组成的一组血清标志物被确定为有效的诊断工具，在训练样本（62例患者和62例对照）中达到0.945的受试者工作特征曲线下面积（AUC），在测试样本（50例患者和48例对照）中达到0.895。此外，通过将尿液β-羟基丁酸盐添加到血清组中的复合组实现了更令人满意的准确度，其在训练集和测试集中均达到AUC 1。血清和尿中多种脂肪酸和酮体含量均显著升高（P<0.01），提示精神分裂症患者脑内葡萄糖供应不足可能导致脂肪酸代谢增加。
Schizophrenia is a severe mental disorder that affects 0.5–1% of the population worldwide. Current diagnostic methods are based on psychiatric interviews, which are subjective in nature. The lack of disease biomarkers to support objective laboratory tests has been a long-standing bottleneck in the clinical diagnosis and evaluation of schizophrenia. Here we report a global metabolic profiling study involving 112 schizophrenic patients and 110 healthy subjects, who were divided into a training set and a test set, designed to identify metabolite markers. A panel of serum markers consisting of glycerate, eicosenoic acid, β-hydroxybutyrate, pyruvate and cystine was identified as an effective diagnostic tool, achieving an area under the receiver operating characteristic curve (AUC) of 0.945 in the training samples (62 patients and 62 controls) and 0.895 in the test samples (50 patients and 48 controls). Furthermore, a composite panel by the addition of urine β-hydroxybutyrate to the serum panel achieved a more satisfactory accuracy, which reached an AUC of 1 in both the training set and the test set. Multiple fatty acids and ketone bodies were found significantly (P<0.01) elevated in both the serum and urine of patients, suggesting an upregulated fatty acid catabolism, presumably resulting from an insufficiency of glucose supply in the brains of schizophrenia patients.
登录
查看更多内容
DOI：
10.1016/j.plefa.2006.02.001
发表时间：
2006-04-01
影响因子：
3
作者：
Bu, B;Ashwood, P;Jin, LW
通讯作者：
Jin, LW
影响因子：
3.7
作者：
Huang JT;Leweke FM;Tsang TM;Koethe D;Kranaster L;Gerth CW;Gross S;Schreiber D;Ruhrmann S;Schultze-Lutter F;Klosterkötter J;Holmes E;Bahn S
通讯作者：
Bahn S
影响因子：
17.7
作者：
Buchsbaum, Monte S.;Buchsbaum, Bradley R.;Hof, Patrick R.
通讯作者：
Hof, Patrick R.
影响因子：
11.3
作者：
Bosveld-van Haandel, Linda;Knegtering, Rikus;van den Bosch, Robert J.
通讯作者：
van den Bosch, Robert J.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y