Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways.
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways.
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DOI：
10.1016/j.ceb.2009.01.002
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发表时间：
2009-02
影响因子：
7.5
通讯作者：
Sheetz MP
中科院分区：
文献类型：
--
作者：
Vogel V;Sheetz MP
细胞运动和力学的许多方面在本质上是周期性的，例如板状伪足或丝状伪足的伸展和收缩。测试环境的伸展和收缩周期所固有的是机械化学信号的产生，这些信号可以改变长期的细胞行为、转录模式和细胞命运。我们刚刚开始在细胞运动的几个方面定义这样的周期，包括周期性收缩，结合和释放的整合素周期以及运动活性的正常振荡。局部细胞收缩和释放的循环直接与细胞外接触（基质或细胞）以及细胞质机械转换器的应力和释放循环相耦合。拉伸可以改变外部物理特性或基质分子暴露的部位以及内部网络;因此，细胞收缩可以引起机械调节的由外向内和内部细胞信号变化的第二波。在某些情况下，外部和内部信号在空间和时间上的整合可以刺激细胞状态从静止到生长或分化的变化。在这篇综述中，我们将发展机械化学循环的基本概念，以及描述和理解机械化学循环的方法。
Many aspects of cellular motility and mechanics are cyclic in nature such as the extension and retraction of lamellipodia or filopodia. Inherent to the cycles of extension and retraction that test the environment is the production of mechano-chemical signals that can alter long-term cell behavior, transcription patterns, and cell fate. We are just starting to define such cycles in several aspects of cell motility, including periodic contractions, integrin cycles of binding and release as well as the normal oscillations in motile activity. Cycles of local cell contraction and release are directly coupled to cycles of stressing and releasing extracellular contacts (matrix or cells) as well as cytoplasmic mechanotransducers. Stretching can alter external physical properties or sites exposed by matrix molecules as well as internal networks; thus, cell contractions can cause a secondary wave of mechano-regulated outside-in and internal cell signal changes. In some cases, the integration of both external and internal signals in space and time can stimulate a change in cell state from quiescence to growth or differentiation. In this review we will develop the basic concept of the mechano-chemical cycles and the ways in which they can be described and understood.
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影响因子：
5.7
作者：
Craig, D;Gao, M;Vogel, V
通讯作者：
Vogel, V
影响因子：
56.9
作者：
Fernandez, JM;Li, HB
通讯作者：
Li, HB
影响因子：
2.9
作者：
Astrof, Nathan S.;Salas, Azucena;Springer, Timothy A.
通讯作者：
Springer, Timothy A.
影响因子：
3.4
作者：
Charras, GT;Horton, MA
通讯作者：
Horton, MA
DOI：
10.1083/jcb.200204153
发表时间：
2002-11-25
期刊：
The Journal of cell biology
影响因子：
--
作者：
Galbraith CG;Yamada KM;Sheetz MP
通讯作者：
Sheetz MP