Human Gut Microbiota and Gastrointestinal Cancer.
Human Gut Microbiota and Gastrointestinal Cancer.
复制标题
人肠道菌群和胃肠道癌。
DOI：
10.1016/j.gpb.2017.06.002
复制
发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Tian Q
中科院分区：
文献类型：
--
作者：
Meng C;Bai C;Brown TD;Hood LE;Tian Q
人类肠道微生物群在人类的健康和疾病状态中都起着至关重要的作用。在过去的十年中，微生物与肿瘤之间的相互作用引起了人们的广泛关注，以了解复杂微生物群落的各种特征，以及微生物群参与癌症预防，致癌和抗癌治疗的可能机制。大量研究表明，微生物生态失调通过多种途径导致癌症易感性。进一步的研究表明，微生物群及其相关代谢产物不仅通过诱导炎症和免疫失调而导致遗传不稳定性，而且还干扰抗癌药物的药效学，从而与癌症发生密切相关。本文主要综述了肠道菌群对胃肠道肿瘤（包括食管癌、胃癌、结直肠癌、肝癌和胰腺癌）的影响，以及饮食、益生元、益生菌、合生元、抗生素和中药对肠道菌群的调节作用。并提出了今后在胃肠道肿瘤防治中值得探讨的新策略。我们希望这篇综述能够全面概述肠道微生物群与GI癌症之间相互作用的研究，这些研究可能会通过改善预防，诊断和治疗来降低癌症发病率和死亡率。
Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways. Further studies have suggested that the microbiota and their associated metabolites are not only closely related to carcinogenesis by inducing inflammation and immune dysregulation, which lead to genetic instability, but also interfere with the pharmacodynamics of anticancer agents. In this article, we mainly reviewed the influence of gut microbiota on cancers in the gastrointestinal (GI) tract (including esophageal, gastric, colorectal, liver, and pancreatic cancers) and the regulation of microbiota by diet, prebiotics, probiotics, synbiotics, antibiotics, or the Traditional Chinese Medicine. We also proposed some new strategies in the prevention and treatment of GI cancers that could be explored in the future. We hope that this review could provide a comprehensive overview of the studies on the interactions between the gut microbiota and GI cancers, which are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, diagnosis, and treatment.
登录
查看更多内容
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
6
作者：
Allsopp, Philip;Possemiers, Sam;Rowland, Ian
通讯作者：
Rowland, Ian
影响因子：
4.6
作者：
Aviles-Jimenez F;Vazquez-Jimenez F;Medrano-Guzman R;Mantilla A;Torres J
通讯作者：
Torres J
影响因子：
5.9
作者：
Brown DG;Rao S;Weir TL;O'Malia J;Bazan M;Brown RJ;Ryan EP
通讯作者：
Ryan EP
影响因子：
5.1
作者：
Chiu, Wen-Ta;Lin, Yi-Ling;Chen, Ruei-Ming
通讯作者：
Chen, Ruei-Ming