Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer.
Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer.
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DOI：
10.1038/srep04202
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发表时间：
2014-02-26
影响因子：
4.6
通讯作者：
Torres J
中科院分区：
文献类型：
--
作者：
Aviles-Jimenez F;Vazquez-Jimenez F;Medrano-Guzman R;Mantilla A;Torres J
我们的目标是描述胃粘膜在发展为肠型癌症时的微生物区系。研究包括非萎缩性胃炎(NAG)、肠化生(IM)和肠型胃癌(GC)各5名患者。取胃组织，提取DNA，应用基因芯片G3芯片进行微生物区系分析。细菌多样性从8到57不等，从NAG到IM再到GC，细菌多样性逐渐下降(p=0.004)。基于283个分类群的Unifrac存在/缺失和加权Unifrac丰度度量，NAG和GC之间观察到显著的微生物区系差异(p<；0.05)。基于238个分类群存在/不存在的HC-AN分析表明，GC和NAG是分开的，而IM与两者都重叠。基于加权Unifrac距离的协调分析表明，在NAG和GC之间存在显著的微生物区系分离，表明44个分类群的丰度显示出跨类别的显著差异。这项研究首次显示胃微生物区系从NAG到IM再到GC的逐渐转变。
We aimed to characterize microbiota of the gastric mucosa as it progress to intestinal type of cancer. Study included five patients each of non-atrophic gastritis (NAG), intestinal metaplasia (IM) and intestinal-type gastric cancer (GC). Gastric tissue was obtained and DNA extracted for microbiota analyses using the microarray G3 PhyloChip. Bacterial diversity ranged from 8 to 57, and steadily decreased from NAG to IM to GC (p = 0.004). A significant microbiota difference was observed between NAG and GC based on Unifrac-presence/absence and weighted-Unifrac-abundance metrics of 283 taxa (p < 0.05). HC-AN analyses based on presence/absence of 238 taxa revealed that GC and NAG grouped apart, whereas IM overlapped with both. An ordinated analyses based on weighted-Unifrac distance given abundance of 44 taxa showing significance across categories revealed significant microbiota separation between NAG and GC. This study is the first to show a gradual shift in gastric microbiota profile from NAG to IM to GC.
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影响因子：
3.7
作者：
Li XX;Wong GL;To KF;Wong VW;Lai LH;Chow DK;Lau JY;Sung JJ;Ding C
通讯作者：
Ding C
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
DOI：
10.1016/j.bpg.2013.03.016
发表时间：
2013-02-01
影响因子：
3.2
作者：
Engstrand, Lars;Lindberg, Mathilda
通讯作者：
Lindberg, Mathilda
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
3.7
作者：
Andersson, Anders F.;Lindberg, Mathilda;Jakobsson, Hedvig;Backhed, Fredrik;Nyren, Pal;Engstrand, Lars
通讯作者：
Engstrand, Lars